SEC16_YARLI
ID SEC16_YARLI Reviewed; 2183 AA.
AC Q6CEV2;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=COPII coat assembly protein SEC16;
DE AltName: Full=Protein transport protein SEC16;
GN Name=SEC16; OrderedLocusNames=YALI0B12694g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC16 family. {ECO:0000305}.
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DR EMBL; CR382128; CAG83061.1; -; Genomic_DNA.
DR RefSeq; XP_500810.1; XM_500810.1.
DR AlphaFoldDB; Q6CEV2; -.
DR SMR; Q6CEV2; -.
DR STRING; 4952.CAG83061; -.
DR EnsemblFungi; CAG83061; CAG83061; YALI0_B12694g.
DR GeneID; 2906817; -.
DR KEGG; yli:YALI0B12694g; -.
DR VEuPathDB; FungiDB:YALI0_B12694g; -.
DR HOGENOM; CLU_231399_0_0_1; -.
DR InParanoid; Q6CEV2; -.
DR OMA; LERWKGA; -.
DR Proteomes; UP000001300; Chromosome B.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0070973; P:protein localization to endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402; PTHR13402; 2.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Autophagy; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..2183
FT /note="COPII coat assembly protein SEC16"
FT /id="PRO_0000295544"
FT REGION 60..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1541..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1693..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2066..2183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..172
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..823
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..989
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1693..1720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1745..1768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1769..1788
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1954..1970
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1994..2022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2076..2106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2120..2134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2183 AA; 229971 MW; EED95D88390C1A3B CRC64;
MRRMFLVSRN GYKRWPEKQK LQTFRVLIST YIFSQPPILA QYHTIPCSNL KLYCRRPRST
MAKKNNKKSK AKAKKAAPSV AVPATNVASS VAADPAAVET ASSTSASLSV PESAAATETT
ASTSPTSPVT NVSPLAEAIA GDEGSGSIPD DEEDIDEEEE TGTEESAEAE AEPESPEGTT
PVLTVQPNAL AAEPTVETVD VVVPVPVEPE EDEQESEVKA EIDPVVAEIE QPEPPMASDK
DFFSTLSKEE DGEEDVKEVA TSTTTDVATP VATATPSITQ VEKHLESRFM GNPVVENEKK
HKEDEIREVE DQLTERLMRD PVVEGIKRER AEESAQVEEK LEKRFMEDPV VEQIKQEQAD
EYRKVRDQLE TGSEEPNDDF FANLGSEEAK LQAKDTEPDT KHEDDFFSTL GGSSDETGKK
TVAETQSEPE TKTIETAKAE EAKPIETKTE PVAEDDFFSG LGKSEQEQGF VPEHTTAAST
TTKEEDDFMA SLAQPQNPEQ TDPLPQDDFF SQLAEENVQS VSAEPEHKSP VAAPAATKAA
AAEDDFFSQL GKSPEKSVPA AATSDDAPRR RHKVQPSGAD FFDQLGVSET EAPPALHEPP
QPKPITLSLD EDDDLLLTDE DDQAEVLAEA GKPNPPVQSF AFLEDDDLLE SDQDFLETDD
EDEEPMAAQT GGDFRANQQH QNTYFPSVPV APVSTSRYST PTVPSVSQFG GYGAAQSTPN
MYQPVSSQST PSAAAPGAGK RVDKNKSDAF DFPTGMIPKV VKKARSQQQL PQAHGAPGVT
PGLMPAFGAA PGAPPTPGVP PMGPPVARPA SNPYAPAPVQ PPTTAPKKNF FEELPPIPVK
PISRQPSYAL SPPRAPFAQE ASQQPRRVSD GYGMPSHGGP HSGVHSAPVS HHNSVSGPPA
AAPHNPYAPP SGPSAVPPKT SSPYAHPPAA VPPKTSSPYA PPPPAVPPKS SSPYAPPPVS
HSAPPAGGPP AGPPRGTSRG VPVPQPQPPV AAAAAAAAAA AAAAGTASGP PPAGPPRVSS
RNAYAPPRGA PPRGTTPPVV APAMAYSPNV SPKRVIQQPQ TQSPRRYSEF KDIGQKSTVS
DEALRKRQFP IFRWSNSKNA TCLIAPQIGY ATAVSQTSVR LLDVSKVVST GEDITRFPGP
LFTPNKGPVK SKKKELEKWV ADHVNLLDSQ NADADRVLLW KLVRVYLAND GVINSAQVRA
FLTPHFEQSA TGDGSAFTSA MDLSSSSFVP QQGDNGPSFS GSDANHVLRH LQSGSKDAAI
RHCMDRRLWG HSMLIASTMG PEKWKDVVSE FIKDDVRPLY KPTLQFLYSS FGGVIPSSEA
YGDWKETVSY LLSNAKDDGS DLSSLVSLGD DLVQKGYVAA GHFCYVVSRA PLTDKITLLG
SEGRDLDAIL LSETYEFALG LKTNVAIPQM QLYKLVHAEV LADLGNVAQA QRYAEYLNQA
LKSFTDKSSI IQPAYISRLI ALSDRVSSTP GATTGSWFSR PKLDKVLGHL DKSLSKFVAG
EEANVAGASS ASDTVFSQIA ATPGISRTTS VVDLSQQSAV TPGYQQHQPY GVPPTRASTG
NILRPQGGSG PYDSRPSLPR SSSAMDAGPS GYGYERAPSV ASVHSVQSDY PRVMSPIDVG
GVSGGNSAYA PVGGAGIYPL PAGGSSAANA YAPGAGGNAN APPSGATANA YTPGATSSGP
SPYALPSGNV YAPPSAPSAS GASPYAPSAS SFSPRQPAYG RSYASTPEHH IEEEEETEAV
DQEQEPAADY SHLENENERY EQKSEPEPEP MAHPPPAQKA PPAAPPAQQA PAQKAGQKPP
ARKVAPPPKP SVKSVYNPYD PGSPAKEKKS SAAASNKYAP ANSAYSPGNS SAPAPTANKE
PEPATTSEAY GYGYGGGYGG YDPYSGYPAA EEEGAEPTET EVENEKAGEA EAAAADYPDY
GVPSYGYQSQ AADDAGDYGD DEGAIYTPAA VTLPPISNLP PVPLPGLEPA TSAAPPASRY
SAPTAAAEEE DDDDFGVGNK KPVAKKEEKK AEEKEEPKDG GKKGWFGGWF KKGEQQPADD
KKVYKAKLGE KSNFYYSEEH KRWINGDLPI EDQIKGAGGP PPPPKAKKPA GPPAGGTPPP
PSGGAPPVGA SRGATPPVAT PPAADTPPVP GAGGAPRPAA TGAPRPKVVD PLEGFLTGGP
PTGAPRKGAR KSAKSRYVDI MNN
