ID   SEC1_DICDI              Reviewed;         598 AA.
AC   Q54QC8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Protein transport protein sec1;
GN   Name=sec1; Synonyms=sec1A; ORFNames=DDB_G0283937;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=17684569; DOI=10.1371/journal.pone.0000724;
RA   Bretscher M.S., Clotworthy M.;
RT   "Using single loxP sites to enhance homologous recombination: ts mutants in
RT   Sec1 of Dictyostelium discoideum.";
RL   PLoS ONE 2:E724-E724(2007).
CC   -!- FUNCTION: Involved in the vesicle trafficking. Binds syntaxins (By
CC       similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Defects in locomotion.
CC       {ECO:0000269|PubMed:17684569}.
CC   -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000058; EAL65456.1; -; Genomic_DNA.
DR   RefSeq; XP_638816.1; XM_633724.1.
DR   AlphaFoldDB; Q54QC8; -.
DR   SMR; Q54QC8; -.
DR   STRING; 44689.DDB0231656; -.
DR   PaxDb; Q54QC8; -.
DR   EnsemblProtists; EAL65456; EAL65456; DDB_G0283937.
DR   GeneID; 8624340; -.
DR   KEGG; ddi:DDB_G0283937; -.
DR   dictyBase; DDB_G0283937; sec1.
DR   eggNOG; KOG1300; Eukaryota.
DR   HOGENOM; CLU_009210_2_0_1; -.
DR   InParanoid; Q54QC8; -.
DR   OMA; ITDRTMD; -.
DR   PhylomeDB; Q54QC8; -.
DR   Reactome; R-DDI-114608; Platelet degranulation.
DR   Reactome; R-DDI-449836; Other interleukin signaling.
DR   PRO; PR:Q54QC8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR   GO; GO:0071470; P:cellular response to osmotic stress; IMP:dictyBase.
DR   GO; GO:0070177; P:contractile vacuole discharge; IMP:dictyBase.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0007009; P:plasma membrane organization; IMP:dictyBase.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.1910; -; 1.
DR   Gene3D; 3.40.50.2060; -; 1.
DR   Gene3D; 3.90.830.10; -; 1.
DR   InterPro; IPR043154; Sec-1-like_dom1.
DR   InterPro; IPR043127; Sec-1-like_dom3a.
DR   InterPro; IPR001619; Sec1-like.
DR   InterPro; IPR027482; Sec1-like_dom2.
DR   InterPro; IPR036045; Sec1-like_sf.
DR   PANTHER; PTHR11679; PTHR11679; 1.
DR   Pfam; PF00995; Sec1; 1.
DR   PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR   SUPFAM; SSF56815; SSF56815; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..598
FT                   /note="Protein transport protein sec1"
FT                   /id="PRO_0000351219"
SQ   SEQUENCE   598 AA;  67773 MW;  0A1545836DD109FA CRC64;
     MATSLRELCK DRILNEMVRT ITPEASNGWK ALIVDQDSLR VISACCGMFD IMEEKVTVVE
     KIDNPRQRLP NLEAIYFLTP TAQSIDLLIN DFKKKSSPHY LAIHLFLTSK LPEVEFKKLS
     ASLAVHRIKT FKEINLEFLA IESQAFHLDQ NNTLFQLFSP DSIDPTEEQA KIATRLVSLC
     VSLNECPIIR FSRSHPVSAM IAGFTQEKLD NVMRTVKSFK PNDDRSTLLI LDRTQDPLAP
     LIHEFSYQAM VYDLFDIEND KFSFDTVTNA GATLKKDVLL GETDYMWSGL RHQHIADVST
     NLTTRLDEFL KTNQVSQYGQ HTGSLKEAGE VVRSLPQYQE MMGKYSVHIN LADRASAKFP
     ELEQLAYLEQ DLATGEDANG NSPKNVTGRL SNYLSDFSAE KYNKIRLLMM YIISQDGIKE
     EDRRRLMEMA GISQSEQNAF TNLRYLGVTL MKGAKGKKPI SPPKNRKSES GNVPYEVSRY
     VPVVKDIAEN IINETLPSTD FPFVKEEPIA RATNAPVSKV SLKGKSKQPR WADPNVQVEE
     TKYSGSKLII FVIGGMTFSE MRSIYELSSH YKKNIYIGST NILLPKKYID QLLTLKNE