SEC1_SCHPO
ID SEC1_SCHPO Reviewed; 693 AA.
AC O94590;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein transport protein sec1;
GN Name=sec1; ORFNames=SPCC584.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in the final stage of protein secretion.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Note=Localizes at the cell tip and
CC barrier septum.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21822.1; -; Genomic_DNA.
DR PIR; T41443; T41443.
DR RefSeq; NP_588226.1; NM_001023216.2.
DR AlphaFoldDB; O94590; -.
DR SMR; O94590; -.
DR BioGRID; 275431; 1.
DR STRING; 4896.SPCC584.05.1; -.
DR iPTMnet; O94590; -.
DR MaxQB; O94590; -.
DR PaxDb; O94590; -.
DR PRIDE; O94590; -.
DR EnsemblFungi; SPCC584.05.1; SPCC584.05.1:pep; SPCC584.05.
DR GeneID; 2538850; -.
DR KEGG; spo:SPCC584.05; -.
DR PomBase; SPCC584.05; sec1.
DR VEuPathDB; FungiDB:SPCC584.05; -.
DR eggNOG; KOG1300; Eukaryota.
DR HOGENOM; CLU_009210_1_0_1; -.
DR InParanoid; O94590; -.
DR OMA; ITDRTMD; -.
DR PhylomeDB; O94590; -.
DR Reactome; R-SPO-114516; Disinhibition of SNARE formation.
DR Reactome; R-SPO-114608; Platelet degranulation.
DR PRO; PR:O94590; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; ISS:PomBase.
DR GO; GO:0006906; P:vesicle fusion; ISS:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..693
FT /note="Protein transport protein sec1"
FT /id="PRO_0000316616"
FT REGION 514..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 79638 MW; F5FD1FC08CEF4BAA CRC64;
MTLLELQKEL FLSKINSVEC ATKWKVLIVD TKTADIINHF ITIHSLLEEK IAAVEILENP
RTPNSSFEAL YILHSEEKLV DCILKDEEYD KRYPGIHIVF LDMVKEPLIN KLRTSRIASK
IRTVQVAYLD FTSLESRYFQ VHDSFSGLRL YHPSNAAIIR QELSKVAHGI FSVCVSLGIS
PNIRCYYPKN APHASKTMSF ILANQLSEIV EEYCSKHPGY HEAASKSTCL IVDRSLDTAA
PFLHEFTYQA MIHDLLPIKN EQYPYEILGP QGTEKRTGKL DDDDLVYTTI RHMHMRDAIE
KLMKDFNQFC IDNTLFLDKE RATSLNDMRS MLAGLSDFQE LRDQYSLHLT MAQECMNIFE
KQQLNLIGAI EQDLSTGSNV EGKVPRSVLS ELLPLLDEGN AEESTKIRLL LLYIIYRDGI
ILQDLFRLFR HSNLSTSREQ IFQNLEQLGT RVIKNLTDQS SKRKEVANSL PAGEDVYELS
RYVPTLKVVL ENLIQDKLDP ELFPYVRNTT PQTEVSMEQT SLRSSRPSWT RSRSMASKLP
REKMLVFVAG GTTFSELRTC YELSDKYNKD IYIGSTVCYS PNEWLDFFSK FQQPREALKF
PEDKPRHIPC LEARPSPNRI QEQPNIDVPS TRYENTSSSD AVSIHKDEKK SKGKSHKLGK
LMMSSKKDKD KSKEKVPTYG TSDKKKKKRF GVF
