SEC1_YEAST
ID SEC1_YEAST Reviewed; 724 AA.
AC P30619; D6VSE4;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Protein transport protein SEC1;
GN Name=SEC1; OrderedLocusNames=YDR164C; ORFNames=YD8358.18C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=1767592; DOI=10.1002/yea.320070613;
RA Aalto M.K., Ruohonen L., Hosono K., Keraenen S.;
RT "Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene
RT localized on chromosome IV.";
RL Yeast 7:643-650(1991).
RN [2]
RP ERRATUM OF PUBMED:1767592.
RX PubMed=1523891; DOI=10.1002/yea.320080710;
RA Aalto M.K., Ruohonen L., Hosono K., Keraenen S.;
RL Yeast 8:587-588(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in the final stage of protein secretion.
CC -!- SUBUNIT: Interacts with MSO1.
CC -!- INTERACTION:
CC P30619; P53604: MSO1; NbExp=3; IntAct=EBI-16833, EBI-2086543;
CC -!- MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000305}.
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DR EMBL; X62451; CAA44308.1; -; Genomic_DNA.
DR EMBL; Z50046; CAA90384.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12004.1; -; Genomic_DNA.
DR PIR; S17479; S17479.
DR RefSeq; NP_010448.1; NM_001180471.1.
DR AlphaFoldDB; P30619; -.
DR SMR; P30619; -.
DR BioGRID; 32215; 335.
DR DIP; DIP-2498N; -.
DR IntAct; P30619; 20.
DR MINT; P30619; -.
DR STRING; 4932.YDR164C; -.
DR iPTMnet; P30619; -.
DR MaxQB; P30619; -.
DR PaxDb; P30619; -.
DR PRIDE; P30619; -.
DR TopDownProteomics; P30619; -.
DR EnsemblFungi; YDR164C_mRNA; YDR164C; YDR164C.
DR GeneID; 851742; -.
DR KEGG; sce:YDR164C; -.
DR SGD; S000002571; SEC1.
DR VEuPathDB; FungiDB:YDR164C; -.
DR eggNOG; KOG1300; Eukaryota.
DR GeneTree; ENSGT00940000174642; -.
DR HOGENOM; CLU_009210_1_0_1; -.
DR InParanoid; P30619; -.
DR OMA; ITDRTMD; -.
DR BioCyc; YEAST:G3O-29754-MON; -.
DR Reactome; R-SCE-114516; Disinhibition of SNARE formation.
DR Reactome; R-SCE-114608; Platelet degranulation.
DR PRO; PR:P30619; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P30619; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0005935; C:cellular bud neck; IDA:SGD.
DR GO; GO:0005934; C:cellular bud tip; IDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0000149; F:SNARE binding; IDA:SGD.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IMP:SGD.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0031340; P:positive regulation of vesicle fusion; IDA:SGD.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IPI:SGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR Gene3D; 3.90.830.10; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 1: Evidence at protein level;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..724
FT /note="Protein transport protein SEC1"
FT /id="PRO_0000206297"
FT REGION 675..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 83480 MW; B3C12AD4E01273B0 CRC64;
MSDLIELQRN YLIGVLNQIE TKNNLKFLII DKTVETILSY LFLTPQELLN NVTSVDLIDS
PTRKGQSSIE AIYILEPTKY NINCIDADFM VRPPKYRRCH IRFLPGLTNP IFQFFQSKRY
IAQNLESFKP IELGFFVKES QFFETLQMEH SLQVFFNNNC KALIPTNVRK IVGSLVSLCV
ITGEYPIVRY SVSNPVEEED ARNGNAVVNA NSLTRSIANA FQIAIDTYAR NNPDFPPQNT
ERPRSILIIT DRTLDPFAPI LHDFSYQAMA YDLVANVDTQ KDIYHYSAEN EAGEQEEKVS
KLVDLYDPDW IDLKHQHIMD ANEYIQGRIK ELIAKNPLLV DRSNVKNTTD LLSVVAHLKD
FDEERRRLIL HKTLVDECLG ENAERKLADI SAIEQNLSGF GMDFSGEKIK HIIDDLLPAL
AMKEPTILDK LRYIIAYALF RGGIIELDFI KLLNFIGVTH EHENFQQYLK IFRNYDLIDF
KLIKDKPKDK PFQKEWFHDT LVNDPNIYHT SRFVPAVGNI LSKVIANPLL LSEQYFPYLK
DKPIELLNEE EFQAGLANTS ANSSSSLRNP RHKAAWTTKS SNIKKNIPRQ RFFYYVIGGI
SIPEIKAAYD QSNLKNRDIF IGSDEILTPT KFLDEVERLQ NPREFFKFKE DQRQQVNPPD
FLLREMKPVA QPVSHVHLKS QDNSPKSGTS SPKAAGSLKS EPPEKEKKRS KFSRFLKRKS
HHDK
