ID   SEC22_CANGA             Reviewed;         215 AA.
AC   Q6FWT0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Protein transport protein SEC22;
GN   Name=SEC22; OrderedLocusNames=CAGL0C03179g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for transport from the ER to the Golgi complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
CC       Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; CR380949; CAG58220.1; -; Genomic_DNA.
DR   RefSeq; XP_445314.1; XM_445314.1.
DR   AlphaFoldDB; Q6FWT0; -.
DR   SMR; Q6FWT0; -.
DR   STRING; 5478.XP_445314.1; -.
DR   EnsemblFungi; CAG58220; CAG58220; CAGL0C03179g.
DR   GeneID; 2886888; -.
DR   KEGG; cgr:CAGL0C03179g; -.
DR   CGD; CAL0127430; CAGL0C03179g.
DR   VEuPathDB; FungiDB:CAGL0C03179g; -.
DR   eggNOG; KOG0862; Eukaryota.
DR   HOGENOM; CLU_054453_4_0_1; -.
DR   InParanoid; Q6FWT0; -.
DR   OMA; ERSYPRK; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:EnsemblFungi.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IEA:EnsemblFungi.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:EnsemblFungi.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:EnsemblFungi.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:EnsemblFungi.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:EnsemblFungi.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR044565; Sec22.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45837; PTHR45837; 1.
DR   Pfam; PF13774; Longin; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..215
FT                   /note="Protein transport protein SEC22"
FT                   /id="PRO_0000206765"
FT   TOPO_DOM        1..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..118
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT   DOMAIN          133..193
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ   SEQUENCE   215 AA;  24986 MW;  61064EF13164D4A0 CRC64;
     MIKSTVVYRD DGLPLCSSVD DDISDLSLNE QKKRIKMVVS RMTPQSANEA TLESKDSEIH
     YIRQQGVIYF VICEAGYPRN LAFSYLNDVA VEFQHSYSNE LSKPTIRPYA FASFDTFLQR
     TKKAYSDKKV QDNLDQLNQE LVGVKQIMSK NIEDLLYRGD SLEKMDDMSN SLKISSKKYR
     KSAQKINFDL LISQYAPIVM VAFFFVFLFW WVFLR