ID   SEC22_KLULA             Reviewed;         214 AA.
AC   Q6CJA0;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Protein transport protein SEC22;
GN   Name=SEC22; OrderedLocusNames=KLLA0F20251g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for transport from the ER to the Golgi complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
CC       Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98697.1; -; Genomic_DNA.
DR   RefSeq; XP_455989.1; XM_455989.1.
DR   AlphaFoldDB; Q6CJA0; -.
DR   SMR; Q6CJA0; -.
DR   STRING; 28985.XP_455989.1; -.
DR   EnsemblFungi; CAG98697; CAG98697; KLLA0_F20251g.
DR   GeneID; 2895472; -.
DR   KEGG; kla:KLLA0_F20251g; -.
DR   eggNOG; KOG0862; Eukaryota.
DR   HOGENOM; CLU_054453_4_0_1; -.
DR   InParanoid; Q6CJA0; -.
DR   OMA; ERSYPRK; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:EnsemblFungi.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IEA:EnsemblFungi.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:EnsemblFungi.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:EnsemblFungi.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:EnsemblFungi.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:EnsemblFungi.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR044565; Sec22.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45837; PTHR45837; 1.
DR   Pfam; PF13774; Longin; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..214
FT                   /note="Protein transport protein SEC22"
FT                   /id="PRO_0000206766"
FT   TOPO_DOM        1..192
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..117
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT   DOMAIN          132..192
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ   SEQUENCE   214 AA;  24899 MW;  31A1E7E0D94E6A0D CRC64;
     MIRSTLIFRE DGLPLCASVD DDTDPSLQEQ KKKVKILISR FTPTSANEAT VESGDFEIHY
     IRLNTVVYIV VAERNYPRNL AFSYLADIQQ EFEHSYGGQL SKSNVRPYEF VSFDNFLQKT
     KKVYNDKRVQ GNMDQLNQDL KGVKQIMTKN IEDLLYRGDS LDKMSDMSAS LRQDAKKYRA
     SAQKINFDLL ISQYAPIAII AFFFVFLLWW MFLR