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SEC23_CRYNB
ID   SEC23_CRYNB             Reviewed;         763 AA.
AC   P0CR39; Q55KV2; Q5KAM7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Protein transport protein SEC23;
GN   Name=SEC23; OrderedLocusNames=CNBJ2310;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC       promotes the formation of transport vesicles from the endoplasmic
CC       reticulum (ER). The coat has two main functions, the physical
CC       deformation of the endoplasmic reticulum membrane into vesicles and the
CC       selection of cargo molecules (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC       SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle,
CC       COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAEY01000050; EAL18308.1; -; Genomic_DNA.
DR   RefSeq; XP_772955.1; XM_767862.1.
DR   AlphaFoldDB; P0CR39; -.
DR   SMR; P0CR39; -.
DR   EnsemblFungi; AAW45976; AAW45976; CNJ01150.
DR   EnsemblFungi; EAL18308; EAL18308; CNBJ2310.
DR   GeneID; 4938574; -.
DR   KEGG; cnb:CNBJ2310; -.
DR   VEuPathDB; FungiDB:CNBJ2310; -.
DR   HOGENOM; CLU_008658_3_0_1; -.
DR   Proteomes; UP000001435; Chromosome 10.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0090114; P:COPII-coated vesicle budding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd11287; Sec23_C; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR037364; Sec23.
DR   InterPro; IPR006900; Sec23/24_helical_dom.
DR   InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR   InterPro; IPR006896; Sec23/24_trunk_dom.
DR   InterPro; IPR012990; Sec23_24_beta_S.
DR   InterPro; IPR037550; Sec23_C.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR006895; Znf_Sec23_Sec24.
DR   InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR   PANTHER; PTHR11141; PTHR11141; 1.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF08033; Sec23_BS; 1.
DR   Pfam; PF04815; Sec23_helical; 1.
DR   Pfam; PF04811; Sec23_trunk; 1.
DR   Pfam; PF04810; zf-Sec23_Sec24; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF81811; SSF81811; 1.
DR   SUPFAM; SSF82754; SSF82754; 1.
DR   SUPFAM; SSF82919; SSF82919; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW   Golgi apparatus; Membrane; Metal-binding; Protein transport; Transport;
KW   Zinc.
FT   CHAIN           1..763
FT                   /note="Protein transport protein SEC23"
FT                   /id="PRO_0000410281"
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         80
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   763 AA;  85146 MW;  1E0D213B818EC233 CRC64;
     MNFEDIEDKD GVRFSWNVWP SSRLEATRTV VPISALYTPL KEREDLPPVM YEPVTCKGSS
     CKAILNPYCQ VDVRGKMWIC PFCLQRNPFP PHYHQDLSPN NLPPELLPKF TTIEYTLSRP
     AQIPPIFLYV VDTCVDEDEL KALKETLVVS LSLLPPNALV GLITYGTMAM VHELAYADCP
     KAYVFRGSKD YQPKQIADML GLNPSNRPIQ PVRPGQPMPA PAASKFLMPV QACEFQLTNI
     LEQLQRDPWP VEQDKRPLRC TGVALSVAVS LLETAFPNTG ARIMLFSGGP ATDGPGMVVG
     PELREPIRSH HDIDRDSVKH FKRASKFYEA LSKRASVNGH AIDIYAGCLD QVGLLEMKSL
     TNATNGVMTI SDSFMTAIFK QSFLRTLGKD EQGYLKMGFN ATYDVLTTKE LKISGVIGHV
     ISANKKSSCV GETEIGIGQT SAWKVCSLTP KSTLATYFEV VTPAGQALTP NQSGLIQFVT
     HYQHSSGQYR LRVTTVSRVF QEGGHPSIAA SFDQEAAAVL MARIAVFKAE IDDSPDVLRW
     LDRMLIRLCQ KFADYRKEDP TSFQLSPNFS IYPQFMFHLR RSQFLQVFNN SPDETAFYRH
     VLNDSDVNNS LIMIQPTLMS YGFDSEPHPV LLDSVSIRPD VILLLDTFFH ILIFHGETIA
     QWRKANYQEQ EDYANFKELL EAPIGDAQEL LEDRMPIPRY VVCDQGGSQA RFLLSKLNPS
     TTHMSGSNYG AGPAGGQAIF TDDVSLQVFM EHLKRLAVGA STS
 
 
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