SEC23_DICDI
ID SEC23_DICDI Reviewed; 750 AA.
AC Q54T59;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Protein transport protein SEC23;
GN Name=sec23; ORFNames=DDB_G0281985;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC sec23/24 complex, the sec13/31 complex, and the protein sar1A or sar1B.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000044; EAL66414.2; -; Genomic_DNA.
DR RefSeq; XP_640392.2; XM_635300.2.
DR AlphaFoldDB; Q54T59; -.
DR SMR; Q54T59; -.
DR STRING; 44689.DDB0235163; -.
DR PaxDb; Q54T59; -.
DR EnsemblProtists; EAL66414; EAL66414; DDB_G0281985.
DR GeneID; 8623347; -.
DR KEGG; ddi:DDB_G0281985; -.
DR dictyBase; DDB_G0281985; sec23.
DR eggNOG; KOG1986; Eukaryota.
DR HOGENOM; CLU_008658_3_0_1; -.
DR InParanoid; Q54T59; -.
DR OMA; FPPHYAE; -.
DR PhylomeDB; Q54T59; -.
DR Reactome; R-DDI-204005; COPII-mediated vesicle transport.
DR Reactome; R-DDI-5694530; Cargo concentration in the ER.
DR Reactome; R-DDI-983170; Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
DR PRO; PR:Q54T59; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd11287; Sec23_C; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR037364; Sec23.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR037550; Sec23_C.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR11141; PTHR11141; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF81811; SSF81811; 1.
DR SUPFAM; SSF82754; SSF82754; 1.
DR SUPFAM; SSF82919; SSF82919; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Transport; Zinc.
FT CHAIN 1..750
FT /note="Protein transport protein SEC23"
FT /id="PRO_0000328077"
SQ SEQUENCE 750 AA; 84701 MW; 5043203EA5C2B509 CRC64;
MNFDQSEDRD GVRFSWNVWP TSRVEATKNL LVPLGCLYTP LHQSPEITQV PYPPLRCKGI
CNAILNPYCT IAPPYKTWVC PFCLQHNQFP PHYAGISDLN RPAELLPHVT TIEYQLPTAE
TPLPIYLFVV DVCVPDDELQ SLTDSLTMSL SLIPENSYVG LITFGSMVQL YELGFTSCPK
SYVFRGDPPT NTFKIANLMQ KVGSPETMNL QSKRFLVPVS ECEFHLTSIL EEIQKDPCRV
ASDKRPLRAT GMAFSVANAL LSTVASNMGG RIMAFIGGPA TTGPGLVVSE DLREPIRSHH
EVIKGKTKYT SKAYQFYKSI GERSVASGHA IDIFSCSLDQ VGLYEMREMV KLTGGYMVLA
DSFDHPMFTQ SFQKIFTRED NAFKMGYNAE VQVCTSMSLK VCGAIGHMSS RNNKTSCVGE
NEIGIGGTSS WKVCALDQNS TFAFYFEIAN TQQNAPEQLG LVQFITSYQN SLGKQILRVS
TIRREWVQHT MEQQQNITML ANGFDQETSA VLMARLAVFK AETEELPDIT RWLDKMLIKL
VSKYADYRRD DPTSFKLVSN FSIYPHFMFH LRRSSFLQVF NSSPDESSFY RFMLNRENVS
NSLIMIQPTL EKYSFSGPPH PEVLSASSIS IDSILLLDTF FHVLIFHGET IAQWRKAGYD
KDPQHQNFRD LLQAPRDDAA HILKERFPYP RYIVCDQHSG EARFLLATID PNITHTSNTP
QDPSKGEIVF TDDVNLHVFL EHLKKFAVQS
