SEC24_ASPCL
ID SEC24_ASPCL Reviewed; 919 AA.
AC A1CUC3;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Protein transport protein sec24;
GN Name=sec24; ORFNames=ACLA_086070;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC sec23/24 complex, the sec13/31 complex, and the protein sar1. Golgi
CC apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle,
CC COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000305}.
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DR EMBL; DS027060; EAW06910.1; -; Genomic_DNA.
DR RefSeq; XP_001268336.1; XM_001268335.1.
DR AlphaFoldDB; A1CUC3; -.
DR SMR; A1CUC3; -.
DR STRING; 5057.CADACLAP00007832; -.
DR EnsemblFungi; EAW06910; EAW06910; ACLA_086070.
DR GeneID; 4700388; -.
DR KEGG; act:ACLA_086070; -.
DR VEuPathDB; FungiDB:ACLA_086070; -.
DR eggNOG; KOG1985; Eukaryota.
DR HOGENOM; CLU_004589_2_1_1; -.
DR OMA; TFPRDQS; -.
DR OrthoDB; 330236at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:EnsemblFungi.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF81811; SSF81811; 1.
DR SUPFAM; SSF82754; SSF82754; 1.
DR SUPFAM; SSF82919; SSF82919; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Transport; Zinc.
FT CHAIN 1..919
FT /note="Protein transport protein sec24"
FT /id="PRO_0000295476"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..269
FT /note="Zinc finger-like"
FT BINDING 244
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 247
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 266
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 269
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 919 AA; 100415 MW; C79B3F95A5D4F87A CRC64;
MAAPQGGYPP QEGYGQPGDY GSPTQQQPGV VAGAAHQGHA GGKKKRAYAG EAFGFGSGAN
AALGGQPPAG GSYGVYPPQP QAAGYQQPVY GADPHQMNAA APGYATPASP GVAQMTQQFG
AMGMTDPHLM PPQPQQAAVT PQAPRPVPLN QLYPTDLLTQ PFNVAELDYP PPPIVLPPGT
SVYPSPQANC PPTYVRSTLN AVPTTHSLLK KSKLPFALVI QPYAALHDAE DPIQVIPDQV
ISRCRRCRSY INPFVTFMDH GHRWRCNMCN LTNDVPQAFD WDSALQKPAD RSLRPDLNHA
VVEFVAPQEY MVRPPQPLVY LFLIDVSYAS VTNGLLATSA RCIKESLDRI PNADRRTRLG
FIAVDSSLHY FSIPRDGSEN SDPRMLVVSD LEEPFLPIPG DLLVTLSECR ENIETFLDKL
QEMFQNTQNN GCAMGSALRA GYKLISPVGG KMTVLSSSLP NIGHGALTMR EDKKVLGTSK
ESSLLQTANS FYKSFAVECS KAQVSVDMFL FSSQYQDVAS LSNLPRYTGG QTYFYPGWNA
ARPEDAIKFA REFSEYLSSE IGLEAVLRVR ATTGLRMNTF YGNFFNRSSD LCAFPAFPRD
QAYVVEVAID ETVTKPVVCL QTAVLHTTCN GERRIRVLTL ALPTTQNLAD VYASADQQAI
ATYFSHKAVE RALSSGLEPA REALQAKAVE LLSTYRKELA GGSVSGGGLQ FPANLRGLPV
LFLALIKNLG LRKSAQIPTD MRSAALCLLS TLPLPLLMQY IYPKMYSLHD MPDNAGLPDE
QTGEIVLPPP VNLSSERIVP YGLYLIDDGQ TQFLWVGRDA VPQLLLDVFG LADRTQLRVG
KQNLPELDND FNQRVRAVIE KSRDHRSKGV GSIVVPHLYV VKEDGEPGLR LWAQTMLVED
RADQSVSLVQ WMGSLREKV
