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SEC24_CRYNB
ID   SEC24_CRYNB             Reviewed;         920 AA.
AC   P0CR41; Q55X19; Q5KMW5; Q5KMW6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein transport protein SEC24;
GN   Name=SEC24; OrderedLocusNames=CNBB5410;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC       promotes the formation of transport vesicles from the endoplasmic
CC       reticulum (ER). The coat has two main functions, the physical
CC       deformation of the endoplasmic reticulum membrane into vesicles and the
CC       selection of cargo molecules (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC       SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi
CC       apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle,
CC       COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic
CC       reticulum membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P0CR41-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0CR41-2; Sequence=VSP_041430;
CC   -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAEY01000011; EAL22368.1; -; Genomic_DNA.
DR   RefSeq; XP_777015.1; XM_771922.1. [P0CR41-1]
DR   AlphaFoldDB; P0CR41; -.
DR   SMR; P0CR41; -.
DR   EnsemblFungi; EAL22368; EAL22368; CNBB5410. [P0CR41-1]
DR   GeneID; 4934637; -.
DR   KEGG; cnb:CNBB5410; -.
DR   VEuPathDB; FungiDB:CNBB5410; -.
DR   HOGENOM; CLU_004589_2_1_1; -.
DR   Proteomes; UP000001435; Chromosome 2.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd01479; Sec24-like; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR006900; Sec23/24_helical_dom.
DR   InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR   InterPro; IPR006896; Sec23/24_trunk_dom.
DR   InterPro; IPR012990; Sec23_24_beta_S.
DR   InterPro; IPR041742; Sec24-like_trunk_dom.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   InterPro; IPR006895; Znf_Sec23_Sec24.
DR   InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF08033; Sec23_BS; 1.
DR   Pfam; PF04815; Sec23_helical; 1.
DR   Pfam; PF04811; Sec23_trunk; 1.
DR   Pfam; PF00397; WW; 1.
DR   Pfam; PF04810; zf-Sec23_Sec24; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF81811; SSF81811; 1.
DR   SUPFAM; SSF82754; SSF82754; 1.
DR   SUPFAM; SSF82919; SSF82919; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cytoplasm; Cytoplasmic vesicle;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Metal-binding; Protein transport; Transport; Zinc.
FT   CHAIN           1..920
FT                   /note="Protein transport protein SEC24"
FT                   /id="PRO_0000410282"
FT   DOMAIN          5..39
FT                   /note="WW"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   REGION          248..273
FT                   /note="Zinc finger-like"
FT   BINDING         248
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         251
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         270
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         273
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..63
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041430"
SQ   SEQUENCE   920 AA;  100339 MW;  1B9090AD7A77A996 CRC64;
     MSQPIMLPQG WEARWDPQAN AYIYVDQSTG RSQWEVPLNP TFPTSPTPHA PPQRHGRRAY
     PSAMYAHAYD TPAPHVGPPQ PVAGYAEQGT PQFITPGFEG QQPVQQPPYA AVDHVAGQFQ
     QMNIAPGAAP VAGAAAGAYQ GAGYAEKQLH STKTKTVNLI GLQPDVAALD NPPPPALLPA
     NASVTSSAHS QPDPSYQRCT LNAMPTTQSL LNKSKLPLAL VMAPYRSIRE TDNDPDVPVV
     EDGVIARCRR CRAYINPFVT FIEGGNRWKC CMCGLSNEVP QLFDWDQRAE KPADRWARKE
     LNHAVVEFVA PTEYMVRPPQ PPVYAFVIDV SSAAIQSGMV AVAARTILES LDSLPNADNR
     TKVAIIAVST SLHFFSLPAD ATEAGMLVVP DLTDVFLPKP VDLLVNLTES RPAIESLLAK
     LSDMFQDSHT VGSALGSGLQ AAHQLIGKIG GKIIALGASL PTIGEGVLKA RDDPKLLGTS
     KESQLLNAGN NWYKTFAIEC SKNQVSVDMF LFSGTYTDVA TLGCLPRYTA GQTYLYPGFN
     ASRSEDAIKF ATEFGKVLAM PIGLEAVIRV RASRGIRMSA FHGNFFIRST DLLALPVVPQ
     DQNYVIELQI EDDIKGSFVV IQTAVLHTTC YGERRIRVIT QAMPTTDSIA ELYTSADQIA
     LATYLANKAV ERSMSHSLDD ARNHVTNRLG EMLTVYKNQV TSAAGGASAQ LAVPENLLLL
     PLLCCALTKH VGLREGASIP PDLRAYAQCL LTTLPCQTLI PYIHPRFYSL HNMPPEAGTI
     GGDDGAMILP PALNLTSEKL ERHGLFLIED GQNIFLWVGH DAVPRLIQDV FDLASYHELQ
     GGKYTLPRLD NPFSERVCNV VDKTREMRRG VYRPQVYVVK SDAEPALRSW ALSLLVEDRM
     DRMSSYAQYL TTVKSKVNGS
 
 
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