SEC24_PICGU
ID SEC24_PICGU Reviewed; 918 AA.
AC A5DPC0;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Protein transport protein SEC24;
GN Name=SEC24; ORFNames=PGUG_05121;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi
CC apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle,
CC COPII-coated vesicle membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endoplasmic
CC reticulum membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000305}.
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DR EMBL; CH408160; EDK41023.2; -; Genomic_DNA.
DR RefSeq; XP_001483166.1; XM_001483116.1.
DR AlphaFoldDB; A5DPC0; -.
DR SMR; A5DPC0; -.
DR STRING; 4929.XP_001483166.1; -.
DR PRIDE; A5DPC0; -.
DR EnsemblFungi; EDK41023; EDK41023; PGUG_05121.
DR GeneID; 5124693; -.
DR KEGG; pgu:PGUG_05121; -.
DR VEuPathDB; FungiDB:PGUG_05121; -.
DR eggNOG; KOG1985; Eukaryota.
DR HOGENOM; CLU_004589_2_1_1; -.
DR InParanoid; A5DPC0; -.
DR OMA; TFPRDQS; -.
DR OrthoDB; 330236at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF81811; SSF81811; 1.
DR SUPFAM; SSF82754; SSF82754; 1.
DR SUPFAM; SSF82919; SSF82919; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport;
KW Golgi apparatus; Membrane; Metal-binding; Protein transport;
KW Reference proteome; Transport; Zinc.
FT CHAIN 1..918
FT /note="Protein transport protein SEC24"
FT /id="PRO_0000295494"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..244
FT /note="Zinc finger-like"
FT COMPBIAS 62..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 219
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 222
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 241
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 244
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 918 AA; 101431 MW; 2539B6088ACD4A25 CRC64;
MSKRRAYPQP QYAISQDQAP ATPPVGASAA YGVPQVAQQF QQMNINPQPG AQPGAAVPQG
YGYNQYGQQP QPGQAYDPYQ QPPQANTGFG GQQQTPSQQP YQQQGGYFGA GAGGQAAPAL
PLNQLYTTDL SRELPPPISD LSLPPPPLVI PSNTAIVPTS EDSNASPDYF RSTLNVIPNN
GTLLKRSKLP LALVVRPYTT LRVDQENIPA ASDTIISRCR RCRCYINPFV TLTEQGRRWR
CNLCNLQNDI PAAFEYDETR GVPRNKFDRV ELNHSVVEFV APKEYMARAP QPIVFVFVID
VSADAVNSGL TSTVTRTILE SLDRIPNQNK TARVAFLGVD SNLHYFRFDE GLEGSELLIA
SDLDEPFLPS PSGLLINLEE NRPAIEKLLI DFPTYFENTA NTQFALGPAL KAGHKMIANI
GGKLITFAAS LPNIGEGKLS VRDEASHSGQ PKESQMLLGA ADKFYKSFAV ECNSAQVTVD
LFLTSARYQD VATLSNLPRF TAGQTHFYPA WSCVKPEDVT KLSKEISEHL SMDIALEAVL
RVRSSTGMRS SAFYGNFFNR SSDLCSFPSF PRDQSYVIEM SIEETITKPV VYFQAASLHS
TSYGERRIRV MNLAIPTSSK LDDIYASADQ LAIANYFTHK AVEKALASSL PDARNYIVKS
IVDILNVYKK ELVAGNVSGS SPLQISTNLR MLPLLLFSLT KHLGLRGERV PSDHRAAALN
RLSSLPIPHL IKYIYPTVYS LHNMGDECGL PEQTVTVNEE TGEEETTSGG ILLPEPINDT
KASWENYGLY LIDNSSEVFL WVSGDVVPDL VYDLFGTDNL YSIPTGKTEL PELQPDESEF
NYRVRNILGK IREQKDQITW KNLYVVIGGS SNEPIEISQQ RDLMALRMWA LSCLVEDKTA
NEQGYREFLT SLKGKVAQ
