ID   SEC2_SCHPO              Reviewed;         527 AA.
AC   O13930;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Rab guanine nucleotide exchange factor sec2;
DE   AltName: Full=GDP-GTP exchange factor sec2;
GN   Name=sec2; ORFNames=SPAC23C4.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Guanyl-nucleotide exchange factor for ypt2. Catalyzing the
CC       dissociation of GDP from ypt2 and promotes the binding of GTP (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC2 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16881.1; -; Genomic_DNA.
DR   PIR; T38265; T38265.
DR   RefSeq; NP_593182.1; NM_001018578.2.
DR   AlphaFoldDB; O13930; -.
DR   SMR; O13930; -.
DR   BioGRID; 278418; 20.
DR   STRING; 4896.SPAC23C4.10.1; -.
DR   iPTMnet; O13930; -.
DR   MaxQB; O13930; -.
DR   PaxDb; O13930; -.
DR   PRIDE; O13930; -.
DR   EnsemblFungi; SPAC23C4.10.1; SPAC23C4.10.1:pep; SPAC23C4.10.
DR   GeneID; 2541930; -.
DR   KEGG; spo:SPAC23C4.10; -.
DR   PomBase; SPAC23C4.10; sec2.
DR   VEuPathDB; FungiDB:SPAC23C4.10; -.
DR   eggNOG; KOG4324; Eukaryota.
DR   HOGENOM; CLU_009486_1_1_1; -.
DR   InParanoid; O13930; -.
DR   OMA; CEFTGYL; -.
DR   PhylomeDB; O13930; -.
DR   Reactome; R-SPO-5620912; Anchoring of the basal body to the plasma membrane.
DR   Reactome; R-SPO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:O13930; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0051286; C:cell tip; HDA:PomBase.
DR   GO; GO:0070319; C:Golgi to plasma membrane transport vesicle; IBA:GO_Central.
DR   GO; GO:0071341; C:medial cortical node; IDA:PomBase.
DR   GO; GO:0090619; C:meiotic spindle pole; IDA:CACAO.
DR   GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR   GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IPI:PomBase.
DR   GO; GO:0006887; P:exocytosis; ISO:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR   InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR   InterPro; IPR009449; Sec2_N.
DR   PANTHER; PTHR14430; PTHR14430; 1.
DR   Pfam; PF06428; Sec2p; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..527
FT                   /note="Rab guanine nucleotide exchange factor sec2"
FT                   /id="PRO_0000097660"
FT   REGION          233..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..171
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        259..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         75
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   527 AA;  59053 MW;  4AB64E24F2EC2E37 CRC64;
     MPDVSNVRVK PNQHPYEKEV NGKLMSQEEI LSQKLVAAIE RQAALDDKYA TEVHRNEALS
     ERIRELEAKL SAKKSFDEEL VKFHNLEEKL QLTETKCRNA ESEKSRVENE LEDLTSSLFE
     EANRMVANAR KETVASEKRV NQLKKQLVDA ETLLSSTQHQ LTELKDVMHS MSDSHEQNNA
     LHPPLSRTTS FVADNVSVGS FASSTSGLDI LTGTSARESL DAKEISSDKH LNISGERPAT
     FPNPTFIEGS DERRSASSLG HRTNNNQNQL IRFSTQIRSS STSPPRSPLI ISDSPSSSII
     HNPHPTHPSA SAMNYMNPCF LEFHAFFNYP MKFARSRSAY STSANYSNTP PRNTVTPSTA
     RSSTLSQNPS SSSNSIPLIS RNLRDFSFFK RCLEEDIEPT LRLDHASGLS WLTRRSVFTA
     ILESSLIINP LHSTSLLSSQ PCSLCGFNRT QPLRQFEFRS RPDSTSHASC TYCVARLRSV
     CNFVAFLHQI CKGVWSSCSL EKAWDECLKK REAMFLSRVG LAKELEG