SEC31_ASPCL
ID SEC31_ASPCL Reviewed; 1276 AA.
AC A1C6X5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Protein transport protein sec31;
GN Name=sec31; ORFNames=ACLA_071790;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC sec23/24 complex, the sec13/31 complex, and the protein sar1. sec13 and
CC sec31 make a 2:2 tetramer that forms the edge element of the COPII
CC outer coat. The tetramer self-assembles in multiple copies to form the
CC complete polyhedral cage. Interacts (via WD 8) with sec13 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC31 family. {ECO:0000305}.
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DR EMBL; DS027045; EAW14146.1; -; Genomic_DNA.
DR RefSeq; XP_001275572.1; XM_001275571.1.
DR AlphaFoldDB; A1C6X5; -.
DR SMR; A1C6X5; -.
DR STRING; 5057.CADACLAP00006389; -.
DR PRIDE; A1C6X5; -.
DR EnsemblFungi; EAW14146; EAW14146; ACLA_071790.
DR GeneID; 4708309; -.
DR KEGG; act:ACLA_071790; -.
DR VEuPathDB; FungiDB:ACLA_071790; -.
DR eggNOG; KOG0307; Eukaryota.
DR HOGENOM; CLU_003033_2_0_1; -.
DR OMA; NRYAPAP; -.
DR OrthoDB; 100998at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR040251; SEC31-like.
DR InterPro; IPR009917; SRA1/Sec31.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13923; PTHR13923; 2.
DR Pfam; PF07304; SRA1; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..1276
FT /note="Protein transport protein sec31"
FT /id="PRO_0000295428"
FT REPEAT 5..47
FT /note="WD 1"
FT REPEAT 66..109
FT /note="WD 2"
FT REPEAT 118..158
FT /note="WD 3"
FT REPEAT 164..204
FT /note="WD 4"
FT REPEAT 208..251
FT /note="WD 5"
FT REPEAT 255..295
FT /note="WD 6"
FT REPEAT 298..338
FT /note="WD 7"
FT REPEAT 382..407
FT /note="WD 8; interaction with sec13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00221"
FT REGION 820..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..879
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1018
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1079
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1114
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 137178 MW; A20D82BC4BAF3C9D CRC64;
MVRLREIPRT ATFAWSPGAA SPLIATGTRA GAVDVDFSNE TCLELWDLGL SNDDASQELQ
PIAKIGTDSG FNDLAWTDSQ DNSRGVIAGA LENGSLDLWD ADKLINGSSD AIISRMTKHS
GAIKALQFNP KHSNLLATGG AKGELYISDL NNIANPYRLG STAARADDIE CLDWNKKVAH
ILVTGSSAGF VTVWDVKTKK ESLTLNNMGR KAVSAVAWDP EKPTKLITST PLESDPLIYV
WDLRNSHAPE RTLKGHESGV LSLSWCPQDP DLLLSSGKDN RTICWNPQSG QAYGEFPVVT
NWTFQTRWNP HNPNFFATAS FDGRISIQTI QNTRTDTAQA IADQNQSLDG EDFFAKAQTQ
PQVSNFSLPK APKWLERPSS ATFGFGGRVV SVGLIEKGKR ASRIKITPFE VDEAVAKSTE
TFETALKEGD LRSICETRAS QAASEEEKAD WKVIEALISG NPRKGLIEYL GFQDQADEAA
DKLAKLGLDK EDVNGDTLTE SRGSGAKKHK RLQSMFDANP EADSFLSDLA ASKGAKTNNP
FHIFTGSESE AEQGITRALL LGNFEKALDV ALKEDRMSDA FVIAICGGQK CIEKAQEHYF
SKQTGGPNYT RLLASIVGKN LWDVVYNADL SNWKEVMAAL CTFADDKEFA DLCEALGDRL
GEQIRSTDDK ALRKDASFCF LAGSKLEKVV AMWIEELREN EQKGIETAAD DTSFSIHVRA
LQGLIEKVTI FRQATNFQDT ERTKEADWKL AMLYDKYIEY ADVVATHGRL QVAQKYLDLV
PEKHPEAEIA RNRIKLAMRQ AAPQRTQSTV PAARTTLNRP LPQINAYPPQ PTFSSPAPPA
PQNPYAPPTA APSQPANPYA PPAAAPSQPS NPYAPPTAAA AIPQPQVNNP YAPIGGGGYT
PAGYQPPQAP AYGVQSLGGG SVPPPPRASN QSPAVTTYTT ATNLPAWNDL PEGFTKPPTS
RRGTPATAAA AISSPFPNQS PTFSQGPPPP GMPPTQRAPS VPPPPKGTVP PPRVTSPPTG
FTPASNLSAP PPAANPYASL PQSPPIGSTM GIPAPASIPR GPSPYNAAPT MPPPSNRYAP
SPAVQAASPQ LATRAAVPPP PPAAASPYAP QPAAQPPVAS SYAPSTPPPS QLPMQQGPPQ
GPPSRPGTAS SQRKAAPAPP KYPPGDRSHI PADAMPIFEI LSADMQRVKT RAPSSFKAQV
DDAERRLNIL FDHLNNEDLL RPNTIADMAE LARAIQARDY ETAKTIHIDI MTNRTDECGN
WMVGVKRLIS MSRATP
