SEC31_CHAGB
ID SEC31_CHAGB Reviewed; 1258 AA.
AC Q2GVT8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Protein transport protein SEC31;
GN Name=SEC31; ORFNames=CHGG_07916;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and
CC SEC31 make a 2:2 tetramer that forms the edge element of the COPII
CC outer coat. The tetramer self-assembles in multiple copies to form the
CC complete polyhedral cage. Interacts (via WD 8) with SEC13 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC31 family. {ECO:0000305}.
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DR EMBL; CH408033; EAQ86663.1; -; Genomic_DNA.
DR RefSeq; XP_001225572.1; XM_001225571.1.
DR AlphaFoldDB; Q2GVT8; -.
DR SMR; Q2GVT8; -.
DR STRING; 38033.XP_001225572.1; -.
DR PRIDE; Q2GVT8; -.
DR EnsemblFungi; EAQ86663; EAQ86663; CHGG_07916.
DR GeneID; 4394267; -.
DR eggNOG; KOG0307; Eukaryota.
DR HOGENOM; CLU_003033_2_0_1; -.
DR InParanoid; Q2GVT8; -.
DR OMA; NRYAPAP; -.
DR OrthoDB; 100998at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR040251; SEC31-like.
DR InterPro; IPR009917; SRA1/Sec31.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13923; PTHR13923; 2.
DR Pfam; PF12931; Sec16_C; 1.
DR Pfam; PF07304; SRA1; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..1258
FT /note="Protein transport protein SEC31"
FT /id="PRO_0000295434"
FT REPEAT 6..46
FT /note="WD 1"
FT REPEAT 65..109
FT /note="WD 2"
FT REPEAT 117..157
FT /note="WD 3"
FT REPEAT 161..201
FT /note="WD 4"
FT REPEAT 204..247
FT /note="WD 5"
FT REPEAT 251..291
FT /note="WD 6"
FT REPEAT 294..334
FT /note="WD 7"
FT REPEAT 375..403
FT /note="WD 8; interaction with SEC13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00221"
FT REGION 470..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..847
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..993
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1139
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1258 AA; 134167 MW; 01A7F0982C5C4321 CRC64;
MVRLREIPRT AAFAWSSGPN PLLVTGTRSG AVDADFSDET KLELWELNLD ALDQGLELQP
VASISTESRF YDIAWGAPSD EHPRGVVAGA MEDGSLQLWD AAKLLAGEEA VMSRDTKHTG
PIKALQFNPL RPQVLATAGS KGELFVWDTN DTSTAFRLGT AAAHDIDCVA WNRKVSNILA
TGSAGGFVTV WDLKTKKASL TLNNNRKPVS AIAWDPTNST NLLTATSDDN TPLILLWNLR
NSQAPEKTLQ GHDQGILSLS WCQQDPGLLI SCGKDNRTLV WNPQTGERYG EFPEATNWTF
LTRFNPGNPN LVATASFDGK ITVQTLQNTN ASVAPAAQTN TDDDDFFAKA PTELQGASFS
LTRAPIWFER PVGVSFGYGG KLITFKKNDT PAGQPRSSKI QISSFSVDSD IGSATEKFEE
AYKRGDIGAI CDSNAADAQT EEEKADWQVL KALSESDGRT KILEYLGFAK DDEASTSPEE
TEVAEPKEEP KETGLAPPQP NGDDAKKKHK RVTSMWGDLD EGDDFLSDLT PAKGAKTDQP
FQLLGEGNTT EDRVTKAIIL GNFEKAVDIC LKEDRVADAF ILANCGGKEL VDKVQTSYLA
QKKGTPSYLR LINSVIGKNL WDVVYNADLG NWKETMVTLC TFAEPSEFPD LCEALGDRIY
ESGSRQDASF CYLVGSKLEK VVDIWVVELQ EAEQAGLQEA SNDSTFSIHA RSLQHFIEKV
TVFRHVIKFA DDEKELTEGW KLGSLYDKYT QYADIVAAHG QLAVAQRYLD LLPTKFPAAE
VARNRVRLAT QKVAPQAPQV AQRQTGPISR AASRGPTPMG YQQPASIPPV GPSHTNPYAP
PAPVQPAASS SNPYAPSTTS QFTPAGASPY APAGYAPPHP APGGYGPPQT FTQPGAPAPP
PPRNTGPPPK IHKDPGSWND VPMVTRPPVR KTTPSVAPIT APFGAQAGLQ SPLPTGPYQR
GAPTPPPPPP KGSAPPRSVT SPPVGPPPAG PYGARPASVT SNTPSPYAPP PAAAAAGLPS
PMVPPPAGRT ASPYNAPPAG PPPSNRYAPA PSAQPYGQGP TPTPLAPPPA NPYAPAPAAQ
QPMAPPPQQY TAPPPQASRP PVGPPPMSGP PPAAGGPPPA ARAAPPQQTP PPPRAAATPP
AARHPAGDRS HIPPDAQRMV ELLSQDMQRV ASKAPATFAP QVKDTQKRLG LLFDHLNNGE
LVRPDTVEQL TAIAEAIAGK NYDAASKGQM EIFRDKVEEC GQWMVGLKRL ISMSKATP
