SEC31_NEUCR
ID SEC31_NEUCR Reviewed; 1256 AA.
AC Q873A1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Protein transport protein sec31;
GN Name=sec31; ORFNames=B24N11.230, NCU06738;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1.
CC Sec13 and sec31 make a 2:2 tetramer that forms the edge element of the
CC COPII outer coat. The tetramer self-assembles in multiple copies to
CC form the complete polyhedral cage. Interacts (via WD 8) with nup-
CC 20/sec13 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC31 family. {ECO:0000305}.
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DR EMBL; BX284751; CAD70409.1; -; Genomic_DNA.
DR EMBL; CM002237; EAA34274.1; -; Genomic_DNA.
DR RefSeq; XP_963510.1; XM_958417.2.
DR AlphaFoldDB; Q873A1; -.
DR SMR; Q873A1; -.
DR STRING; 5141.EFNCRP00000006817; -.
DR EnsemblFungi; EAA34274; EAA34274; NCU06738.
DR GeneID; 3879671; -.
DR KEGG; ncr:NCU06738; -.
DR VEuPathDB; FungiDB:NCU06738; -.
DR HOGENOM; CLU_003033_2_0_1; -.
DR InParanoid; Q873A1; -.
DR OMA; NRYAPAP; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR040251; SEC31-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13923; PTHR13923; 2.
DR Pfam; PF12931; Sec16_C; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..1256
FT /note="Protein transport protein sec31"
FT /id="PRO_0000295442"
FT REPEAT 5..46
FT /note="WD 1"
FT REPEAT 65..109
FT /note="WD 2"
FT REPEAT 117..157
FT /note="WD 3"
FT REPEAT 161..201
FT /note="WD 4"
FT REPEAT 204..247
FT /note="WD 5"
FT REPEAT 251..291
FT /note="WD 6"
FT REPEAT 294..334
FT /note="WD 7"
FT REPEAT 375..403
FT /note="WD 8; interaction with sec13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00221"
FT REGION 473..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..1005
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1052
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1145
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 134018 MW; F3875155C99C36B3 CRC64;
MVRLREIPRT AAFAWSPGAN PLLVTGTRSG AVDADFSDET KLELWDLKLD SQEQGLELQP
IASITAESRF YDIAWGQPND EHPRGVIAGA MENGSLDLWD AEKLIAGEDA LISRTTKHTG
PIKALQFNPL RPQVLATAGA KGELFVWDVN DTSAPFRLGT AAAHDIDCLA WNPKVANILA
TGGAGGFVTV WDLKTKKASL TLNNHRKAVS AIAWDPENST KLLTASSDDT APVILLWNLR
NSQAPEKTLQ GHDQGILSLS WCQQDAGLLL SCGKDNRTLI WNPQTGERYG EFPEATNWTF
YTRFNPHNPN LSATASFDGK IAIQTLQNTN PSAAPAAQNN LSDDDFFSKA ASQPQAASFS
LPRAPAWIER PVGVSFGFGG KLVFFNKVET AAGQKRSSKL QISSFSIDSD IGSATDKFEQ
AIQSGDIASI CEEHIENAKT DEEKAEWQVM QTLSESDGRT KIIERLGFIK DEPVEEAKEA
ESPMSPEPKQ EDSASLKPNG GEAKKHRRVV SMWGDGDDGE DFLSEIAATK GAKTDNPFNL
LSVGNTHLED QITRALILGK FEKAVEICLK EERWSDAFLI ANCGSKELVE KVQTAYLQQK
RGSPSYLRLI SSVVAKNLWD IAYNADLADW KETMVTLCTY ADPSEFPDLC EALGDRILES
GNRKDASFCY LIGSKLEKVV GLWVDELQET EQAALNEEAG DSTFSVHAKS LQQFIEKVTI
FRHVTKFNDS ETSLTEGWKL AALYDKYLEY ADIAAAHGQL SVAQKYLDLL PTSYPPAETA
RNRVRLATQK AGAQTAVRQA TPAGRTTTTT SSRTAAPVGY QQPSLVPAPA NPSSLNPYAP
PVPAPVSAAA SNPYAPPLAP VSAAASQYGA SSSTYAPPQN QGYAPSGYTP PTQSYAPTSV
TGYGVPAQNF GQPSPLGGPP KATAPPVQLK RDGVWNDVPM VTKAPPRRNT PSVAPLTSPF
PGQPGIASPP PAGPFQQGAP TPPPPPKGSA PPRNVGAPPT GPPRPSSVSS NATNPYAPPP
PAAGLQPTYG VPPAPRTASP YNPPPSAAAP PANRYAPAPA TQQYTQGPPS GSGIAPPPAS
GAYTPAPPAA SQQYAAAPPP PRAGFSAPPP ASRPPGGGPP PAAGAPPQQQ APPPAAPPKP
RYPPGDRSNI PEHAKELVDI LSRDMQRVAS KAPASFAPQV KDTQKRLNIL FDHLNNEELI
KTETIDQLAQ LAGALAGKNY DIASKIQVEI SKEKTEECGQ WMVGVKRLIS MSKATP
