ID   SEC5_SCHPO              Reviewed;         815 AA.
AC   O94598;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Exocyst complex component sec5;
GN   Name=sec5; ORFNames=SPCC622.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the exocyst complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Note=Localized at the cell tip and barrier septum.
CC   -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA21866.1; -; Genomic_DNA.
DR   PIR; T41490; T41490.
DR   RefSeq; NP_588182.1; NM_001023172.2.
DR   AlphaFoldDB; O94598; -.
DR   BioGRID; 275907; 2.
DR   STRING; 4896.SPCC622.10c.1; -.
DR   iPTMnet; O94598; -.
DR   MaxQB; O94598; -.
DR   PaxDb; O94598; -.
DR   PRIDE; O94598; -.
DR   EnsemblFungi; SPCC622.10c.1; SPCC622.10c.1:pep; SPCC622.10c.
DR   GeneID; 2539341; -.
DR   KEGG; spo:SPCC622.10c; -.
DR   PomBase; SPCC622.10c; sec5.
DR   VEuPathDB; FungiDB:SPCC622.10c; -.
DR   HOGENOM; CLU_336540_0_0_1; -.
DR   OMA; MQLIEWA; -.
DR   PRO; PR:O94598; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0051286; C:cell tip; HDA:PomBase.
DR   GO; GO:0000145; C:exocyst; ISS:PomBase.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR   InterPro; IPR029175; EXOC2/Sec5.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   PANTHER; PTHR13043; PTHR13043; 1.
DR   Pfam; PF15469; Sec5; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Exocytosis; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..815
FT                   /note="Exocyst complex component sec5"
FT                   /id="PRO_0000374043"
FT   REGION          37..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   815 AA;  92711 MW;  A5A54C79401CF69B CRC64;
     MSADEEILAH YGLTSLSQDY WTEKPDFAIA NASVDVQSPT TGVHHERNRS EDILRTGGAT
     SETTKDASAA GPVTPSFAMK RSQTSVQPSM SSQIAIGGMR NPMATRKIAG TYRDAPDNSM
     QQTSTGVHRS SSWLTTDGTH QLLSLMETNF NKFIAAKETI DNVYAQIIST LSHAGPAKTM
     DMCEESISGA LQQLQLFNTE STNEVDISYG ELLVMRECEA LFTYPEKFRL YHKQEKYSLL
     MQEIENAKKL YEKDRERLAK VNPKLVYLVD HAWEIIQATI DGICASIWNQ ILQSQGDFAF
     VVRTLCDLLK LKPNPISGRD PVLYATVSQQ KYLYNLMKER FSYFEKIIKS RQEDFSKLSC
     TRASPMLVWR AVARGCNLDY TLRGRPEVFA GMQLIEWANA CVLKIVREIK EVELYAKEFI
     SGIQQASYPE AAKHYGRDPK QMGVVVEKLN SQCLEMVYSF VGERGERLEM DGAFVLIQLH
     YFQRVADLLP KRIRTVFSMA ATRCIVDTWM LQHAPQSKSA NIEEMFIVDA NENQVLEPEL
     MVVDVLRELN KLYIPPHREE IVREIHHAFY KVLYANARFP SMSVSMANWE SDVWSLASST
     LIDFVQHRNQ HDMKKLASKM TTSLPVFSTS ITRSDVLHFV TRLLNLRSRL VPYQKFLLQT
     FPLNEVSPSL DPRISKSLRN LQDLYKLLAI RDTSFSNTTP SSISKLSIQP PTFQLFSTLE
     TIYLELKDSM PPNEAADWMI ATTSCMLAQF ALHSPYAFFH DIPSISHFLN KCLPPTILDL
     LQQIQRKAEA SSISPTTETA TKTRLKFQFI EMIFS