ID   BFRD_BORPE              Reviewed;         743 AA.
AC   P81549;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Probable TonB-dependent receptor BfrD;
DE   AltName: Full=Virulence-associated outer membrane protein Vir-90;
DE   Flags: Precursor;
GN   Name=bfrD; Synonyms=vir90; OrderedLocusNames=BP0856;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   PROTEIN SEQUENCE OF 31-50.
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=10079522; DOI=10.1111/j.1574-6968.1999.tb13442.x;
RA   Passerini de Rossi B.N., Friedman L.E., Gonzalez Flecha F.L.,
RA   Castello P.R., Franco M.A., Rossi J.P.F.C.;
RT   "Identification of Bordetella pertussis virulence-associated outer membrane
RT   proteins.";
RL   FEMS Microbiol. Lett. 172:9-13(1999).
CC   -!- FUNCTION: Probably involved in iron transport.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; BX640413; CAE41159.1; -; Genomic_DNA.
DR   RefSeq; NP_879666.1; NC_002929.2.
DR   RefSeq; WP_010930039.1; NZ_CP039022.1.
DR   AlphaFoldDB; P81549; -.
DR   SMR; P81549; -.
DR   STRING; 257313.BP0856; -.
DR   TCDB; 1.B.14.1.16; the outer membrane receptor (omr) family.
DR   PRIDE; P81549; -.
DR   KEGG; bpe:BP0856; -.
DR   PATRIC; fig|257313.5.peg.911; -.
DR   eggNOG; COG4774; Bacteria.
DR   HOGENOM; CLU_008287_9_1_4; -.
DR   OMA; TANYVHT; -.
DR   Proteomes; UP000002676; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR030148; Fiu.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR039423; TonB-dep_rcpt.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR32552; PTHR32552; 1.
DR   PANTHER; PTHR32552:SF68; PTHR32552:SF68; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Iron;
KW   Iron transport; Membrane; Receptor; Reference proteome; Signal; TonB box;
KW   Transmembrane; Transmembrane beta strand; Transport; Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000269|PubMed:10079522"
FT   CHAIN           31..743
FT                   /note="Probable TonB-dependent receptor BfrD"
FT                   /id="PRO_0000034743"
FT   MOTIF           726..743
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   743 AA;  81581 MW;  CBB631C84AA68246 CRC64;
     MKFYSSHPMP ESLAAAIAVP LLGLLPAAQA ASTAVQLPSV TVEGEYSSYQ PESAQSPKFT
     APLADTPRTV QVIPERLIQD QGASDLEAVL RNAPGISMTA GEGGRPASDL PFIRGQNSAS
     SLFVDGLRDP STQSRDTFNL EQVDVVKGPD SVFSGRGGAG GSINLVTKTP RNQDFTEVQA
     GIGTAETYRG TIDGNWVLGE NTALRLNLLG TRDTVPGRDK AVEFSRVGIA PSLRLGLSGP
     TRVTLGLYHY RHRRVPDYSI PYDPRTGTPI TETIGVSRRN FYGLVRRDSG DTEDYAATVK
     WEHDLANGFK VENLARYSRA TVEQITTMPE LKTADLAKGL VYRNLRASYQ VNDSFANRTD
     LRGTFDTGQW RHTFDLGGEF ATSRRSRDRY KQEIPDAASP CSPVTDGNNP ALCASLRDPD
     PHVDFPGTVR RNHNPARYHT DILSLYGFDT IAFDEQWQLN LGLRWDHYKT SGRNLPVRGA
     KPPVYERAAR TDNLFNYQLG LVYKPRPDGS VYASYGTAST PSAVSDYAPA DSISGTSQQL
     KPERSEAIEI GTKWQVLDRR LLVTGAMFRE TRKNTSIEVA EGLRAPAGKS RVTGMELGVA
     GSLTPRWDVY GGYALLDSKL VRASHKSGAQ GQPLPSAPRH AFSIWSTYKL LPELTVGAGA
     FYRSKVYGNA DAGYNKDGTP KARWVPAYWR FDAMAAYQLN KHLTAQLNVY NLLDKTYYAK
     TYRSHYAALG PGRSAMLTFK LSY