SEC62_ASHGO
ID SEC62_ASHGO Reviewed; 244 AA.
AC Q75D26;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Translocation protein SEC62;
GN Name=SEC62; OrderedLocusNames=ABR196C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Required for preprotein translocation. {ECO:0000250}.
CC -!- SUBUNIT: Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and
CC SEC72. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC62 family. {ECO:0000305}.
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DR EMBL; AE016815; AAS50969.2; -; Genomic_DNA.
DR RefSeq; NP_983145.2; NM_208498.2.
DR AlphaFoldDB; Q75D26; -.
DR SMR; Q75D26; -.
DR STRING; 33169.AAS50969; -.
DR PRIDE; Q75D26; -.
DR EnsemblFungi; AAS50969; AAS50969; AGOS_ABR196C.
DR GeneID; 4619255; -.
DR KEGG; ago:AGOS_ABR196C; -.
DR eggNOG; KOG2927; Eukaryota.
DR HOGENOM; CLU_040936_1_0_1; -.
DR InParanoid; Q75D26; -.
DR OMA; FKPLYGW; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0031207; C:Sec62/Sec63 complex; IEA:EnsemblFungi.
DR GO; GO:0071256; C:translocon complex; IEA:EnsemblFungi.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR InterPro; IPR004728; Sec62.
DR InterPro; IPR011553; Sec62_asco.
DR PANTHER; PTHR12443; PTHR12443; 1.
DR Pfam; PF03839; Sec62; 1.
DR TIGRFAMs; TIGR00869; sec62; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..244
FT /note="Translocation protein SEC62"
FT /id="PRO_0000206620"
FT TOPO_DOM 1..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..158
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 244 AA; 28406 MW; F667149F532C2A75 CRC64;
MSDPESPLWV ATLLRHHKEL KQRQGMFQSR HMEFFRFKRF VRALNSDEYR AKSEREPEKY
PPVRSEEDAR DVFVSLIKAQ LVLPCTKLHT AQCREHGLAP SKDYPHLLLS TKATLDADEY
YVWTHNPKTL TDYLTVVGVI VGILAFVCYP LWPHSMKRVV YYLSLGLLGL LAVFSALALV
RFVIYVLSLA FCSERGGFWI FPNLFEDCGV IASFKPLYGF GETECYGYIK KQKRRKRKLE
KKKQ
