ID   SEC62_CANLF             Reviewed;          39 AA.
AC   P82009;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Translocation protein SEC62;
DE   AltName: Full=Translocation protein 1;
DE            Short=TP-1;
DE   Flags: Fragments;
GN   Name=SEC62; Synonyms=TLOC1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBUNIT.
RC   TISSUE=Pancreas;
RX   PubMed=10860986; DOI=10.1073/pnas.97.13.7214;
RA   Tyedmers J., Lerner M., Bies C., Dudek J., Skowronek M.H., Haas I.G.,
RA   Heim N., Nastainczyk W., Volkmer J., Zimmermann R.;
RT   "Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant
RT   proteins in dog pancreas microsomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:7214-7219(2000).
RN   [2]
RP   SUBUNIT.
RX   PubMed=10799540; DOI=10.1074/jbc.275.19.14550;
RA   Meyer H.-A., Grau H., Kraft R., Kostka S., Prehn S., Kalies K.-U.,
RA   Hartmann E.;
RT   "Mammalian Sec61 is associated with Sec62 and Sec63.";
RL   J. Biol. Chem. 275:14550-14557(2000).
CC   -!- FUNCTION: Mediates post-translational transport of precursor
CC       polypeptides across endoplasmic reticulum (ER). Proposed to act as a
CC       targeting receptor for small presecretory proteins containing short and
CC       apolar signal peptides. Targets and properly positions newly
CC       synthesized presecretory proteins into the SEC61 channel-forming
CC       translocon complex, triggering channel opening for polypeptide
CC       translocation to the ER lumen. {ECO:0000250|UniProtKB:Q99442}.
CC   -!- SUBUNIT: The ER translocon complex that consists of channel-forming
CC       core components SEC61A1, SEC61B and SEC61G and different auxiliary
CC       components such as SEC62 and SEC63 (PubMed:10860986, PubMed:10799540).
CC       Interacts with SEC61B (By similarity). {ECO:0000250|UniProtKB:Q99442,
CC       ECO:0000269|PubMed:10799540, ECO:0000269|PubMed:10860986}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- TISSUE SPECIFICITY: Pancreas.
CC   -!- SIMILARITY: Belongs to the SEC62 family. {ECO:0000305}.
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DR   eggNOG; KOG2927; Eukaryota.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transport.
FT   CHAIN           <1..>39
FT                   /note="Translocation protein SEC62"
FT                   /id="PRO_0000206615"
FT   NON_CONS        18..19
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4498 MW;  6E77E7237BD5DF79 CRC64;
     MGHRVDYFIA SKAVDXLLMK YDKDIKKEKE KGKAESGKE