ID   SEC62_KLULA             Reviewed;         246 AA.
AC   Q6CLZ9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Translocation protein SEC62;
GN   Name=SEC62; OrderedLocusNames=KLLA0E24200g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for preprotein translocation. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and
CC       SEC72. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC62 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAH00127.1; -; Genomic_DNA.
DR   RefSeq; XP_455040.1; XM_455040.1.
DR   AlphaFoldDB; Q6CLZ9; -.
DR   SMR; Q6CLZ9; -.
DR   STRING; 28985.XP_455040.1; -.
DR   EnsemblFungi; CAH00127; CAH00127; KLLA0_E24157g.
DR   GeneID; 2894338; -.
DR   KEGG; kla:KLLA0_E24157g; -.
DR   eggNOG; KOG2927; Eukaryota.
DR   HOGENOM; CLU_040936_1_0_1; -.
DR   InParanoid; Q6CLZ9; -.
DR   OMA; GLWLYPN; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0031207; C:Sec62/Sec63 complex; IEA:EnsemblFungi.
DR   GO; GO:0071256; C:translocon complex; IEA:EnsemblFungi.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IEA:EnsemblFungi.
DR   InterPro; IPR004728; Sec62.
DR   InterPro; IPR011553; Sec62_asco.
DR   PANTHER; PTHR12443; PTHR12443; 1.
DR   Pfam; PF03839; Sec62; 1.
DR   TIGRFAMs; TIGR00869; sec62; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..246
FT                   /note="Translocation protein SEC62"
FT                   /id="PRO_0000206624"
FT   TOPO_DOM        1..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..168
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   246 AA;  28172 MW;  E789F6696F3DC1FA CRC64;
     MSEPSPQSTI AIANLLRTHS DLKQRQGLFQ SRLVDFFRYK RFVRALKSDK YKAKSKKQPE
     LYPAVTSDED ARNIFVSLIK AQFVVPAVKL HSAECKEHGL KPNKSYPNLL LSNKATLQPD
     EYYVWSYNPK SIYDYLTVIG IIVGVLAFVC YPLWPPYMKR GTYYLSIAAL ALIGVFFGIA
     IVRLIVYLLS LAAVSEKGGF WLFPNLFEDC GVIESFKPLY GFGEKECYSF LKKEKRKHRS
     VAKKQK