ID   SEC62_YARLI             Reviewed;         396 AA.
AC   Q99161; Q6CE92;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Translocation protein SEC62;
GN   Name=SEC62; OrderedLocusNames=YALI0B17512g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   PubMed=9021129; DOI=10.1007/s002940050186;
RA   Swennen D., Joyet P., Gaillardin C.;
RT   "Cloning the Yarrowia lipolytica homologue of the Saccharomyces cerevisiae
RT   SEC62 gene.";
RL   Curr. Genet. 31:128-132(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for preprotein translocation. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and
CC       SEC72. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the SEC62 family. {ECO:0000305}.
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DR   EMBL; X99537; CAA67878.1; -; Genomic_DNA.
DR   EMBL; CR382128; CAG83273.1; -; Genomic_DNA.
DR   RefSeq; XP_501020.1; XM_501020.1.
DR   AlphaFoldDB; Q99161; -.
DR   SMR; Q99161; -.
DR   STRING; 4952.CAG83273; -.
DR   EnsemblFungi; CAG83273; CAG83273; YALI0_B17512g.
DR   GeneID; 2907281; -.
DR   KEGG; yli:YALI0B17512g; -.
DR   VEuPathDB; FungiDB:YALI0_B17512g; -.
DR   HOGENOM; CLU_040936_1_0_1; -.
DR   InParanoid; Q99161; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IBA:GO_Central.
DR   InterPro; IPR004728; Sec62.
DR   InterPro; IPR011553; Sec62_asco.
DR   PANTHER; PTHR12443; PTHR12443; 1.
DR   Pfam; PF03839; Sec62; 1.
DR   TIGRFAMs; TIGR00869; sec62; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..396
FT                   /note="Translocation protein SEC62"
FT                   /id="PRO_0000206626"
FT   TOPO_DOM        1..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..178
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..396
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          252..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        236
FT                   /note="A -> V (in Ref. 1; CAA67878)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   396 AA;  44902 MW;  59B0327796FDAF7A CRC64;
     MTENVPQGQI TMPLQQGGAR EISPQALAVA DYLRSHKLLK QRPGILNGKR SDFFRVKRAI
     RALEDPKYKQ LQSKPNSKLP PINSRNEAIS IFRLMPINQM ALRVDKLPTQ TALMMKQKPE
     QGVPVLQVNP QQEFGDDMYY TWFYNPVPLT TYLYGALGVA AIFAGVLFPL WPIFLRQGVW
     YLSVGMLGLI GVFFGIALVR LVIFVLTWPT VKPGIWIFPN LFADVGFVDS FIPLWAWHGT
     PERDLLPQKF KNKKKKKNAG TVIESKEPPR KLTKEEKQKQ KEANAQMEQM QAAFQTQLSS
     FATQMQQIKE MSDSGIDPQI IAAQLQAQYP PDKQAAIKLE NEQAQAKLDE RIRELAAQIQ
     DKTNANKTGD KIEEVADKEN KEAPKRIVTL EDANDE