ID   SEC63_CANLF             Reviewed;          33 AA.
AC   P82008;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Translocation protein SEC63 homolog;
DE   Flags: Fragments;
GN   Name=SEC63; Synonyms=SEC63L;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBUNIT.
RC   TISSUE=Pancreas;
RX   PubMed=10860986; DOI=10.1073/pnas.97.13.7214;
RA   Tyedmers J., Lerner M., Bies C., Dudek J., Skowronek M.H., Haas I.G.,
RA   Heim N., Nastainczyk W., Volkmer J., Zimmermann R.;
RT   "Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant
RT   proteins in dog pancreas microsomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:7214-7219(2000).
CC   -!- FUNCTION: Mediates cotranslational and post-translational transport of
CC       certain precursor polypeptides across endoplasmic reticulum (ER).
CC       Proposed to play an auxiliary role in recognition of precursors with
CC       short and apolar signal peptides. May cooperate with SEC62 and
CC       HSPA5/BiP to facilitate targeting of small presecretory proteins into
CC       the SEC61 channel-forming translocon complex, triggering channel
CC       opening for polypeptide translocation to the ER lumen (By similarity).
CC       Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to
CC       the plasma membrane of the primary cilia (By similarity).
CC       {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000250|UniProtKB:Q9UGP8}.
CC   -!- SUBUNIT: The ER translocon complex consists of channel-forming core
CC       components SEC61A1, SEC61B and SEC61G and different auxiliary
CC       components such as SEC62 and SEC63. {ECO:0000269|PubMed:10860986}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- TISSUE SPECIFICITY: Pancreas.
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DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Chaperone; Direct protein sequencing; Endoplasmic reticulum; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transport.
FT   CHAIN           1..>33
FT                   /note="Translocation protein SEC63 homolog"
FT                   /id="PRO_0000071096"
FT   NON_CONS        18..19
FT                   /evidence="ECO:0000305"
FT   NON_TER         33
SQ   SEQUENCE   33 AA;  3802 MW;  F3F4CC6A83100CFE CRC64;
     AGQQFQYDDS GNTFFYQMAE VFEKEQSIXA AXE