ID   SEC65_ASHGO             Reviewed;         261 AA.
AC   Q756H7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65; OrderedLocusNames=AER289W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52970.1; -; Genomic_DNA.
DR   RefSeq; NP_985146.1; NM_210500.1.
DR   AlphaFoldDB; Q756H7; -.
DR   SMR; Q756H7; -.
DR   STRING; 33169.AAS52970; -.
DR   EnsemblFungi; AAS52970; AAS52970; AGOS_AER289W.
DR   GeneID; 4621358; -.
DR   KEGG; ago:AGOS_AER289W; -.
DR   eggNOG; KOG3198; Eukaryota.
DR   HOGENOM; CLU_065433_1_1_1; -.
DR   InParanoid; Q756H7; -.
DR   OMA; KVKGFKM; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR   GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR   GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..261
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135204"
SQ   SEQUENCE   261 AA;  29514 MW;  2213D3C0B22C7C54 CRC64;
     MPKLEEIDDL EDIDNLHMDL AELDASLKTP IAPRLKPTVV RSQDSEPPLF PQIPLEGEQG
     PSFTFIDPKS GRVEETTKIT KEDLADLKRF QILYPCYFDK NRTHAQGRQV PLELAVANPL
     AKTIADACRE LEVLCVFEGE KTHPQDFGNP GRVRVLLKEN GKAAGKYANK RWLMKNVAKY
     LQEHPTTLES LREIPYGPDF EGIEPSKIPL VHGFQMNEIV PLHSPFTMGH PMTKGIYTAP
     KVVAPEKQIK APKNKYKVVR R