ID   SEC65_CANAX             Reviewed;         275 AA.
AC   O14415;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CA124;
RA   Hartley J.E., Rosamond J.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; U69696; AAC33399.1; -; Genomic_DNA.
DR   AlphaFoldDB; O14415; -.
DR   SMR; O14415; -.
DR   VEuPathDB; FungiDB:CAWG_01516; -.
DR   VEuPathDB; FungiDB:CR_01660C_A; -.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Ribonucleoprotein; RNA-binding; Signal recognition particle.
FT   CHAIN           1..275
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135205"
FT   REGION          28..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31125 MW;  FBC91127438959AB CRC64;
     MSNNKRPVLE EVDDDDIDNM DMDIAEFDPS LTTPIAPKRP EPTVVRSQDS EPSLFPNIPS
     NQVQPPPKQA SSRNGIMDPN SFTEEEKKQF DQFQIIYPCY FDINRSHKQG RRVSIDRAVE
     NPLATTISDA CRRLGLPVFL ELDKTHPQDF GNPGRVKVLF KAVFDNGKLI NPKLQTKRVL
     FNVIAEYLSE HPTTLESIGP KSGVPRPPEF ENDFQPEEIP KVKGFKMNTI VPIHSNLTLK
     HPMTKHIYDP EPETPAAGKP NVPKIPKKKV MKIRG