ID   SEC65_DEBHA             Reviewed;         269 AA.
AC   Q6BM93;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65; OrderedLocusNames=DEHA2F07370g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 andSRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89015.1; -; Genomic_DNA.
DR   RefSeq; XP_460678.1; XM_460678.1.
DR   AlphaFoldDB; Q6BM93; -.
DR   SMR; Q6BM93; -.
DR   STRING; 4959.XP_460678.1; -.
DR   PRIDE; Q6BM93; -.
DR   EnsemblFungi; CAG89015; CAG89015; DEHA2F07370g.
DR   GeneID; 2903262; -.
DR   KEGG; dha:DEHA2F07370g; -.
DR   VEuPathDB; FungiDB:DEHA2F07370g; -.
DR   eggNOG; KOG3198; Eukaryota.
DR   HOGENOM; CLU_065433_1_1_1; -.
DR   InParanoid; Q6BM93; -.
DR   OMA; KVKGFKM; -.
DR   OrthoDB; 1552706at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..269
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135207"
FT   REGION          30..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   269 AA;  30435 MW;  011376F9692058DE CRC64;
     MAKRPVLEDV LDDEIDNMDM DIAQFDPSLR TPIAPVQPGP QITRSQDQEP PLFPNFPHPE
     QDKSVERKDI VDPNKFSAEE RAELKKFQII YPCYFDKSRS HKDGRRVSES KAVSNPLAKT
     ISDACRHYNL PVMLELDKTH PQDFGNPGRV RVLIKDNNKN GMPVDSRFKT KRAVLNIIAD
     YLKTHPTTLA SIGPKSGIPL PSEYETGFEP GEIPKVKGFK MNTIVPVHSE LTIKHPMTKS
     IYDPEPEQPQ VKAPQAPKQP KKKVMKIRG