ID   SEC65_ENCCU             Reviewed;         137 AA.
AC   Q8SRC3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65; OrderedLocusNames=ECU08_0800;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; AL590448; CAD26386.1; -; Genomic_DNA.
DR   RefSeq; NP_597210.1; NM_001041819.1.
DR   AlphaFoldDB; Q8SRC3; -.
DR   SMR; Q8SRC3; -.
DR   STRING; 284813.Q8SRC3; -.
DR   GeneID; 859632; -.
DR   KEGG; ecu:ECU08_0800; -.
DR   VEuPathDB; MicrosporidiaDB:ECU08_0800; -.
DR   HOGENOM; CLU_154721_0_0_1; -.
DR   InParanoid; Q8SRC3; -.
DR   OMA; TVFMPRT; -.
DR   OrthoDB; 1552706at2759; -.
DR   Proteomes; UP000000819; Chromosome VIII.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..137
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135208"
FT   REGION          90..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   137 AA;  16122 MW;  3B71BB9B0138BC2A CRC64;
     MESKHFCLYP IYMDSARSLS EGRKYRKEIC VQRPRYHEIK NALEKLEIEY TDEPSKKHPR
     DFFNSGRFRI KKEYGRLFVI EGISQTIAEL RSKPGSSEET SREKQSRGKA VHGVVQNGVY
     VENKLNLVRK KKAKKKK