ID   SEC65_KLULA             Reviewed;         270 AA.
AC   O13475; Q6CSD6;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65; OrderedLocusNames=KLLA0D01925g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-270.
RC   STRAIN=ATCC 56498 / CBS 683 / DSM 4394 / IFO 1090 / NRRL Y-8279;
RX   PubMed=10509020;
RX   DOI=10.1002/(sici)1097-0061(19990930)15:13<1393::aid-yea452>3.0.co;2-f;
RA   Bai X., Larsen M., Meinhardt F.;
RT   "The URA5 gene encoding orotate-phosphoribosyl transferase of the yeast
RT   Kluyveromyces lactis: cloning, sequencing and use as a selectable marker.";
RL   Yeast 15:1393-1398(1999).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00249.1; -; Genomic_DNA.
DR   EMBL; AJ001358; CAA04695.1; -; Genomic_DNA.
DR   RefSeq; XP_453153.1; XM_453153.1.
DR   AlphaFoldDB; O13475; -.
DR   SMR; O13475; -.
DR   STRING; 28985.XP_453153.1; -.
DR   PRIDE; O13475; -.
DR   EnsemblFungi; CAH00249; CAH00249; KLLA0_D01925g.
DR   GeneID; 2892774; -.
DR   KEGG; kla:KLLA0_D01925g; -.
DR   eggNOG; KOG3198; Eukaryota.
DR   HOGENOM; CLU_065433_1_1_1; -.
DR   InParanoid; O13475; -.
DR   OMA; KVKGFKM; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IEA:EnsemblFungi.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..270
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135209"
FT   REGION          237..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  30065 MW;  95D93669F570F6F9 CRC64;
     MPVIEEIDDI DDIDNLEMDL AELDSTMKTP VAPKIVPTVV RSQDQEEEAY SAAISGNAGS
     GSGFNFVNST TGQVEKSHSL TKEELDEIKE FQMLYPCYFD TRRTHAQGRR APKDLCVENP
     LAKTIADAAR SLGIPSIFEG SKTHPQDFGN PGRVRVLIKE NGKPFVSGID NKRVLMKRIG
     EYLKSHPTTL ESVKQLPYGP DFDNVEPKKI PLLKGTAMND IVPLHSPYLT QHPMTKSLYD
     APPPPPPAQQ VSAPEKQMKM PKNKFRVVRR