ID   SEC65_YARLI             Reviewed;         310 AA.
AC   P41922;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Signal recognition particle SEC65 subunit;
GN   Name=SEC65; Synonyms=SRP19; OrderedLocusNames=YALI0F21505g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   PubMed=9426009; DOI=10.1016/s0378-1119(97)00496-4;
RA   Sanchez M., Beckerich J.-M., Gaillardin C., Dominguez A.;
RT   "Isolation and cloning of the Yarrowia lipolytica SEC65 gene, a component
RT   of the yeast signal recognition particle displaying homology with the human
RT   SRP19 gene.";
RL   Gene 203:75-84(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RA   Sanchez M., Dominguez A.;
RT   "Gene order in a 10275 bp fragment from Yarrowia lipolytica including
RT   YlURA5 and YlSEC65 adyacent genes conserved in four yeast species.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Signal-recognition-particle assembly has a crucial role in
CC       targeting secretory proteins to the rough endoplasmic reticulum
CC       membrane. It must be involved intimately in the translocation of a wide
CC       variety of protein substrates (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54,
CC       SEC65, SRP21 and SRP14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; Z22570; CAA80293.1; -; Genomic_DNA.
DR   EMBL; AJ006754; CAB55335.1; -; Genomic_DNA.
DR   EMBL; CR382132; CAG78522.1; -; Genomic_DNA.
DR   PIR; JC6516; JC6516.
DR   RefSeq; XP_505711.1; XM_505711.1.
DR   AlphaFoldDB; P41922; -.
DR   SMR; P41922; -.
DR   STRING; 4952.CAG78522; -.
DR   EnsemblFungi; CAG78522; CAG78522; YALI0_F21505g.
DR   GeneID; 2908961; -.
DR   KEGG; yli:YALI0F21505g; -.
DR   VEuPathDB; FungiDB:YALI0_F21505g; -.
DR   HOGENOM; CLU_065433_0_0_1; -.
DR   InParanoid; P41922; -.
DR   OMA; GEANNDM; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR   GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR   GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR   Gene3D; 3.30.56.30; -; 1.
DR   HAMAP; MF_00305; SRP19; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   InterPro; IPR022938; SRP19_arc-type.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..310
FT                   /note="Signal recognition particle SEC65 subunit"
FT                   /id="PRO_0000135211"
FT   REGION          24..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  35487 MW;  D65EC9F0C80114C3 CRC64;
     MAILEEIDDV DNMDFDPAEF DPRAVLTDAT AHQESDGRGP INLISKAEHE RREQAKKQQE
     QQQEQQQQAN PMAQLQQMMD QMNQGGGMPP NMGQQGKPGT QVFDSEEFKN QEIQESDFKD
     WQIVYPVYFD KNKTVGEGRR VPLELAVENP LGQTIAEACK MLTLPSIYEA HKTHPKDWAN
     PGRVRVQLKD DPALGLPPHS VKNKRHLFRL IAQYMKEHPT KEVTPYQGPV FQKIIQTNPE
     FPWNSKNLPP KPQYPRGWKM PEILPILSPA LSHGEANNDM MEQMANQFMP KIPEAPPQQK
     VKKMKVRVGR