SEC6_SCHPO
ID SEC6_SCHPO Reviewed; 752 AA.
AC O74846;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Exocyst complex component sec6;
GN Name=sec6; ORFNames=SPCC1235.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP IDENTIFICATION IN THE EXOCYST COMPLEX, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11854409; DOI=10.1091/mbc.01-11-0542;
RA Wang H., Tang X., Liu J., Trautmann S., Balasundaram D., McCollum D.,
RA Balasubramanian M.K.;
RT "The multiprotein exocyst complex is essential for cell separation in
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 13:515-529(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000269|PubMed:11854409}.
CC -!- SUBUNIT: The exocyst complex is composed of sec3, sec5, sec6, sec8,
CC sec10, sec15, exo70 and exo84. {ECO:0000269|PubMed:11854409}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cell
CC septum {ECO:0000269|PubMed:11854409}. Cell tip
CC {ECO:0000269|PubMed:11854409}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the SEC6 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA21114.2; -; Genomic_DNA.
DR PIR; T40884; T40884.
DR RefSeq; NP_587736.2; NM_001022731.2.
DR AlphaFoldDB; O74846; -.
DR SMR; O74846; -.
DR BioGRID; 275526; 34.
DR STRING; 4896.SPCC1235.10c.1; -.
DR SwissPalm; O74846; -.
DR MaxQB; O74846; -.
DR PaxDb; O74846; -.
DR EnsemblFungi; SPCC1235.10c.1; SPCC1235.10c.1:pep; SPCC1235.10c.
DR GeneID; 2538952; -.
DR KEGG; spo:SPCC1235.10c; -.
DR PomBase; SPCC1235.10c; sec6.
DR VEuPathDB; FungiDB:SPCC1235.10c; -.
DR eggNOG; KOG2286; Eukaryota.
DR HOGENOM; CLU_011776_2_0_1; -.
DR InParanoid; O74846; -.
DR OMA; MNIGPKT; -.
DR PRO; PR:O74846; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0051285; C:cell cortex of cell tip; IDA:PomBase.
DR GO; GO:1902716; C:cell cortex of growing cell tip; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0090726; C:cortical dynamic polarity patch; IDA:PomBase.
DR GO; GO:0000145; C:exocyst; IDA:PomBase.
DR GO; GO:0097575; C:lateral cell cortex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0051601; P:exocyst localization; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR Gene3D; 1.10.357.70; -; 1.
DR InterPro; IPR010326; EXOC3/Sec6.
DR InterPro; IPR042532; EXOC3/Sec6_C.
DR PANTHER; PTHR21292; PTHR21292; 1.
DR Pfam; PF06046; Sec6; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Exocytosis; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..752
FT /note="Exocyst complex component sec6"
FT /id="PRO_0000118930"
SQ SEQUENCE 752 AA; 85854 MW; F76F741793C88915 CRC64;
MTAAASDDAV YNKVADILRQ CEDFHRLSTH IERFEREQAS LNMHVKTELE KHVEAVELGK
LALHDAQTKR VKLLQELHNM LTLCESAREM VDEFPLISRM SRIYKNCYAT KQMISQLNNL
VKETDVIEDM LREDLELDSD MPNLLRAHYK LSKLREFREE ALYQASLEGQ SDLPITLENS
FSNLNTLSDN FDRLVLNFCR NIFQLVKSGH IKTIVQIFKI VEAEESSDEV LKSIRDAKSS
LPDSQDGPFL SLQGMTRQLR NFRLRVLEEF QGAAAENFQR AWVSYLEDGS GELNLDFIFE
DLKVAFYVLP DLTPPSYNIA KTFASIYQEC LVGLVTKAVS LDTPAAVYLY LINFHREYRK
FFEENAPFSV DEVEPGLEDG KDGILVREYT RLFTQKIREW SDKLFQSSVD TFMKRESEPE
LDSDGNYGLQ GTIIFFQMIT QQINIISHTN NSDVVGIVLS SIMYIMQSMQ DQWKSVMRSE
LSQQLSGNPE SVPPGLMEYL LAVANDNLKC AGFMDNTLLN TFELITSERE EDLREAFGKT
VDGYILISDI GVSQIVAIIS NDVKPALTSL FQPNWYQSSN MKLIVDTFRD YIVDCIEHMV
PGLFDVFLLE ASNALTISYL RSIFNKNACF DGDNAIQQIR SDIALAIRVF GEYMAAEHLR
STFEPIEKLL LGMLDADVET VSEYFHLLKE AYWDAPLSLV EAVLQNRTDL EKSIIKKMID
IVRHENDSLQ IDTSQQPTVF SQVTSLSGSS IL
