ID   SEC7A_SCHPO             Reviewed;        1811 AA.
AC   Q9UT02; O14168;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Protein transport protein sec71;
GN   Name=sec71; Synonyms=sec7a; ORFNames=SPAC4D7.01c, SPAP8A3.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; THR-326; SER-332;
RP   SER-353; SER-741 AND THR-742, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: May play a role in protein transport. {ECO:0000250}.
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DR   EMBL; CU329670; CAB55182.1; -; Genomic_DNA.
DR   PIR; T38792; T38792.
DR   PIR; T39252; T39252.
DR   RefSeq; NP_594954.1; NM_001020385.2.
DR   AlphaFoldDB; Q9UT02; -.
DR   SMR; Q9UT02; -.
DR   BioGRID; 280024; 2.
DR   STRING; 4896.SPAC4D7.01c.1; -.
DR   iPTMnet; Q9UT02; -.
DR   MaxQB; Q9UT02; -.
DR   PaxDb; Q9UT02; -.
DR   PRIDE; Q9UT02; -.
DR   EnsemblFungi; SPAC4D7.01c.1; SPAC4D7.01c.1:pep; SPAC4D7.01c.
DR   GeneID; 2543610; -.
DR   KEGG; spo:SPAC4D7.01c; -.
DR   PomBase; SPAC4D7.01c; sec71.
DR   VEuPathDB; FungiDB:SPAC4D7.01c; -.
DR   eggNOG; KOG0929; Eukaryota.
DR   HOGENOM; CLU_000691_1_1_1; -.
DR   InParanoid; Q9UT02; -.
DR   OMA; TCIYLDI; -.
DR   PhylomeDB; Q9UT02; -.
DR   PRO; PR:Q9UT02; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR   GO; GO:0005798; C:Golgi-associated vesicle; ISO:PomBase.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:PomBase.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; ISO:PomBase.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032629; DCB_dom.
DR   InterPro; IPR015403; Sec7_C.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   InterPro; IPR032691; Sec7_N.
DR   Pfam; PF16213; DCB; 1.
DR   Pfam; PF09324; DUF1981; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF12783; Sec7_N; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1811
FT                   /note="Protein transport protein sec71"
FT                   /id="PRO_0000120215"
FT   DOMAIN          692..880
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   REGION          1..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..661
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         326
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         332
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         353
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         741
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         742
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   1811 AA;  206932 MW;  14AC990BB746804D CRC64;
     MTDLEIETVS RVSSNPDEVK GSSVVEEEPD SESTIKSRVS DEIDEHDSIP EQSNTEKSIE
     INDKNLEAEK DIESNLSLRP PEDDLDSRSI ESEQTGTLSK QTTSTSEAPQ DLKIWKNISN
     ASNQNSGKLN PQLFVIEAFK HMSKAKATKR HKKLREAINN VQIELQKQPF LLPEVILEPL
     VMACQTNSTT LLTITLDCFA KLIDYNYFDS PTLNPSDITL MERVVNTIAS CFCGESTPER
     VQLQIVKALL AAITSERTII RHSFLLTAVR QTYNIFLLCK DSTTQAIAQV ALLQMVDSVF
     QRLSTVLNHE REFSTINMNK SSSNGTPDRA NSPIPSQLSE NKLTLESFEH RKSFDQVREE
     APLEEDSLEQ QLLRDAFLLI RALCKLSIKN IPYEHEYDLK SQSMRSKLMS LHLIYHILRT
     YMNILSDINV KIRSPTSTPT PLIDAVKQYI CLALAKNVVS HVLPVFEISC EIFWLILSEL
     KNFFKSELEV FFTEIFFPIL EMRTSSNQQK IVLLNIFHRM CEEPQTLIEL YLNYDCISGN
     TENIYERAIV TLSRIASQST SDPPPSFVFR DDQLVIDKPG FVYHTLNDIP QLNSSTIGSY
     VHSHNPPYFD YQIRLKSYRC LISTLSSLFT WCNQTFAPTV EITAKDDETE STSKGEEPQK
     SKSEPPSAGI NSTSMDNLES SGQALATDDP SQFENLKHRK KQLQEAIQKF NYKPKEGIKI
     LLSSHFIASK TPTDIAKFLI STEGLDKAVL GEYLGEGNDE NIAIMHSFVD HMSFNDIPFV
     NALRSFLQKF RLPGEAQKID RFMLKFAEKY IDDNLGVFKN ADTAYILAYS IIMLNTDLHS
     PQVKNRMTCQ DFIKNNRGVD DGANLSDSFL TEVYEEIQKN EIVLKDEQDP TSNFPEIPGT
     SNLSFAANIS NALATVGRDL QREAYYMASN KMANKTEALF KDLIREQRER GKLSGNDIYY
     TARHFEHVCP MFEAVWMPIL AAFSEPLQLS SDPALIQLSL DGFRLAMNVI FFFSMDLPRN
     AFMQTLTKFT HLNNTSELKW TNMHALKTLL EISLAHGDKL RDSWKDVLLC ISQLERVQLI
     SAGVDINSLP DVSTTKPLRK SLDKNIRQSR SGSISLKHSK SFQSASTHST KSSSVEIVRE
     YSSREVVMAV DMLFSNTRNL GSEGIYDFVK ALIEVSWEEI ECSLELSNPR LFSLQKLVEI
     SYYNMRRIRM EWSSIWSLLG TYFTQVSCHE NSIIASFALD SLRQFSMQFL EIEELSHFKF
     QKDFLQPFSH AMENSQDLKI KDLVLRCIDQ MIKARYQNIR SGWRTIFHIL AYASKIENLL
     VLQCAISVVS SLGHEHISCV LTQGAYIDLI SCITKFAKLN GNQKFCLSCV DMLKNLEHEL
     IKHLKHMKKE SVYSKKLEEE YWLPFLLSFN EIICEASDLE VRSKALKVLF DCLYRHADDF
     DEEFWETVSN KALLSIFSIL SITNSQRLYL AKNTEETEVW MLTTMVEALK AFIELIKNLF
     ERLHFLLPKA LNLLEKCICQ ENSMISKVGL SCFSQFVLKN KNQFKDVDWD EIINSINQLL
     QMTLPIELRD PSLYPQVNSD SSLEDVKENS FRPHEISRFN SQSVFKSKKH HLKSIVVKCT
     LQLLMLNCLW ELFHSDNMLT NIPKRKMVKL LDILKQSWEF AESFNSDFEI RAKILSSGIV
     EHMPNLLSQE ALCAKLYFYT AFECMSSLKS DSHDTEEYND LMDVFQKKIY LASQLVLHGF
     QRVIGDNPVK GVAAFQPVIA ALVSYINSLD EIQFSRGKSE FYQLLCAIVA CGHIDQQLGT
     SLSNAFLRYA C