SEC7B_SCHPO
ID SEC7B_SCHPO Reviewed; 1822 AA.
AC Q9P7V5;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Protein transport protein sec72;
GN Name=sec72; Synonyms=sec7b; ORFNames=SPAC30.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44; SER-122; SER-125;
RP THR-597; SER-653; THR-654; SER-669; SER-1110; SER-1606 AND SER-1609, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: May play a role in protein transport. {ECO:0000250}.
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DR EMBL; CU329670; CAB66460.1; -; Genomic_DNA.
DR PIR; T50207; T50207.
DR RefSeq; NP_594555.1; NM_001019984.2.
DR AlphaFoldDB; Q9P7V5; -.
DR SMR; Q9P7V5; -.
DR BioGRID; 278583; 45.
DR STRING; 4896.SPAC30.01c.1; -.
DR iPTMnet; Q9P7V5; -.
DR MaxQB; Q9P7V5; -.
DR PaxDb; Q9P7V5; -.
DR PRIDE; Q9P7V5; -.
DR EnsemblFungi; SPAC30.01c.1; SPAC30.01c.1:pep; SPAC30.01c.
DR GeneID; 2542107; -.
DR KEGG; spo:SPAC30.01c; -.
DR PomBase; SPAC30.01c; sec72.
DR VEuPathDB; FungiDB:SPAC30.01c; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_000691_1_1_1; -.
DR InParanoid; Q9P7V5; -.
DR OMA; DLYITFF; -.
DR PhylomeDB; Q9P7V5; -.
DR PRO; PR:Q9P7V5; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005938; C:cell cortex; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000137; C:Golgi cis cisterna; IDA:PomBase.
DR GO; GO:0005798; C:Golgi-associated vesicle; ISO:PomBase.
DR GO; GO:0005635; C:nuclear envelope; IDA:PomBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:PomBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; ISO:PomBase.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Sec7_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR InterPro; IPR032691; Sec7_N.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF09324; DUF1981; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF12783; Sec7_N; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR SUPFAM; SSF48425; SSF48425; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1822
FT /note="Protein transport protein sec72"
FT /id="PRO_0000120216"
FT DOMAIN 701..889
FT /note="SEC7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 44
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 597
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 653
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 654
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 669
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1110
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1606
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 1609
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 1822 AA; 206800 MW; 25735B503386DDB0 CRC64;
MQDASEPVIN MPALPMNSVN EQHDRHEDLP EVGTTSVTKI INDSDNEDDE NGMDLGRVAS
ESLEGDAVVS IDINTEDSSL SPAKQENEKS PEGIEQKYQE EDLKDDKKSN ETIATPVPDA
ASRASLEKQK SGLTNLEKST HVVLIKCIEQ LIQIKVCMKN EKMKNLMEQL KPLLQTECQF
DKFLIVELFQ YCFESSQDEV MNISLDTISK LASFAYFSSK DKTPASFGPP KSLLQCMVDM
VCDSINDEVV DGNLQLNVVK ALSAFILCSE QDSMLHGAIL LNSVRKLFNV FLLGDSDTIQ
SVAQASLTQA VTVVYERLRA SHTQSNSTSA LPEEDASVTE NWVHDEDEPD KKITLHSMAS
AGTSSLDHVK VDADDPAVTS VENSSIQDAF LVFRSMCRLA VRQTSPDKVS NIRSQAMRAK
LISLHLIYRI LEKNSDLFMD PTLQFRGIPA LKGMTLVHAS RQYICLVLSR NAVSPVPQVF
EVCCDIFYLM VFSLRAHFKQ EIEVFFREVY FPMLDLKNTS YNQKLHTLLI IQRICLNPRA
LVELYINYDC DRSSTTNVFE QLLFSISKVT TNGPSETISE DIEEILPSLE SSERSSTPFL
NTNSASLKSE VVQLTTFSDF QLKLKTLQCV LDILQSLSNW AESGLYLSRR GVSTDEQGFV
GDYDALSRSD TPVTNPYYNG KQSFEANSHS SSSIALADPS QFESNKQRKK LLRTCINKFN
YKPTRGLKML SENEYVDIND PKAIAEFLFR ADGIDKTTLG DYLGEGDEKS ISVMHEFIDC
LSFINLKFVD ALRRLLQCFR LPGEAQKIDR IMLKFSERYM KENPSAFANA DTAYILAYSI
ILLNTDLHSP RIKNKMTKED FIKNNRGIND GADLDEDYLG FVYDDILKNE IAMKDDQELA
AIAPLMNNFS TSSGFTTFTS NGRDLQRVAC IQASEEMANK ATSVLKKLLY QQKHGSQKTN
VYYNATHFEH IGPMLEATWM PILAALSNPL QNSDYVNELN MCLDGFQLVV RIACLFDLDL
IRDAFIKTLT NFTNLHSTSE IKLRNTMVIK TLLRIASTEG NNLKDSWKDI LTIISQLERV
QLIGVGVDET EVPDVINARV RRKNVNIGSS NSIRHVSGST SRSTRTRSLS KPLSPEAVSE
LMSTEVVLSI DRIFTQTSSL SGSAIVSFFK ALCEVSWDEI TSSSDLEQPR LYSLQKLVEI
SYYNMQRIRV EWSSIWNVLG RFFNMVGSDE NRHVAVFALD SLRQLSMHFL EIEELSLFSF
QKEFLKPFEY VMASDTVVEV KELVLQCVKQ MIQAKISKIK SGWKTLFGVF TFAAKARSEI
LISMTFDTLV NLFSEHYDTL MQQNCLIDML ISFTELCKNG TNQKISLQSL EIIREVYSSL
STMIKEGLSS KPSVNETFSK YVFPVLFAYY DIIMSAEDLE VRSRALQNLF YIFLEESDDF
TEETWEVVSR KFIFPIFSIF GPEADEATVM LRDEEIRTWQ STTLVEALRS LVTLLTRRFD
KLHNLLKGYL WLFSNCICRD NITLSRIGTN CMQQLLSGNA YRFEVKDWNL VADMFIELFK
ETTPHQLLLL ETFSNGQGAP VYSENENTQL SHKRGGSLPE TSRSISTSSI SPEKQMEFRS
MIRKCILQLL LISIVAELLD NEEVFNHIPH EHVLKITVAI YDSWQFARKF NEDKSLRITL
LNVGFMKQLP NLLRQETASA LLYITLLFRL LKTRDPLGKT ETDQKIHKLL FPVCAEMLDM
YASLVVEKHT RNHAAWQPVI ATILDSILNL PLELFSENIH TLYFSCCSMI AKENLDDQLR
ELLKNYFNRV GHILLNLNAQ QE
