SEC7C_SCHPO
ID SEC7C_SCHPO Reviewed; 1082 AA.
AC O13817; O13937;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Protein transport protein sec73;
GN Name=sec73; Synonyms=sec7c; ORFNames=SPAC19A8.01c, SPAC23H3.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May play a role in protein transport. {ECO:0000250}.
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DR EMBL; CU329670; CAB11637.1; -; Genomic_DNA.
DR PIR; T38294; T38294.
DR RefSeq; XP_001713067.1; XM_001713015.2.
DR AlphaFoldDB; O13817; -.
DR SMR; O13817; -.
DR BioGRID; 280578; 1.
DR STRING; 4896.SPAC19A8.01c.1; -.
DR iPTMnet; O13817; -.
DR MaxQB; O13817; -.
DR PaxDb; O13817; -.
DR PRIDE; O13817; -.
DR EnsemblFungi; SPAC19A8.01c.1; SPAC19A8.01c.1:pep; SPAC19A8.01c.
DR PomBase; SPAC19A8.01c; sec73.
DR VEuPathDB; FungiDB:SPAC19A8.01c; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_283444_0_0_1; -.
DR InParanoid; O13817; -.
DR OMA; NAFAYCD; -.
DR PhylomeDB; O13817; -.
DR Reactome; R-SPO-199992; trans-Golgi Network Vesicle Budding.
DR Reactome; R-SPO-5620916; VxPx cargo-targeting to cilium.
DR Reactome; R-SPO-6807878; COPI-mediated anterograde transport.
DR Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-SPO-6811438; Intra-Golgi traffic.
DR PRO; PR:O13817; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; ISM:PomBase.
DR GO; GO:0006887; P:exocytosis; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0023052; P:signaling; NAS:PomBase.
DR Gene3D; 1.10.1000.11; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48425; SSF48425; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..1082
FT /note="Protein transport protein sec73"
FT /id="PRO_0000120217"
FT DOMAIN 1..84
FT /note="SEC7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT DOMAIN 193..349
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 122592 MW; E505DB11DFCC8FCB CRC64;
MTFRIPSSQE SSNKSEKDTT VNSPNASSFS SFFKKSSQTY LSKRSEKLNE HNSKLKSSGS
FTSNSQTDLS NSPSSKKKNI FYPIARAKHS FYFNHNWSSD LQQANSPVAS YSSQSVSNDS
NFPKDVTSPI STDLSGSNPS LKSPSSINSA KLRASRSFFR FPKWSRKSWN PDVNSTTSSP
SEVGSLDKAG GPLNQQNENL SAESDNTILQ NGTRKSSVKM SDLGKRIASL PVVKRPPIQF
SISSDYIKPV DKSDQTSNVP SPSSSVGSLR LYRSPSIPND VEQPQPQSSR SRPRSSTIPT
QRTLERLREN RSSIFSFRTL RRDDDECVAQ TIENSALFSD IKPNPTKFLS SVPELTADDT
AESYLSKLRE TVPYSRMIPV LAEKDHVTLN KALHLCMSGM EFENRPLDFC LRLFLLKSHL
PKETQQIDRV INAFSKRYFE CNPGMFSSQD QCYILVFSLM MLHTDVFNSN NKHKMTKQEF
INLCDIDELA PEIMEYYYDN ITFTPFVNLD DELLLIEKEK NEKYNFTSRK RLGLSPYTFT
LENQLNISRP EISLSYDGKF ISPGIKDIAS LLNVRKLISS PAIIQLVSKR SHPMAFSNHF
IGLPDNADPG LVDFSISMLG ILPRCEKKRR SVGHNSYKEH LVLLTASRIL FFRNLVWAKD
LMAQKKAYER RYKNFTTTSS SFDTLQGIDT EAMEYEFPKI PPLVFTPPLE EFSPDTSYSL
VNAFAYCDRD KKNVRNCSFT VIFRDGSEET LCAPTEESMI EWVAKINYIS TLRTAGLRMP
VSDSYHPKRD FSCYPKYMEE ELAAIEAQMK QDMEIARART IKTRIDQLET SITEFNKKLM
VLQRNAKNLS TCAPLQPKTR VVILQALKKV DAKAQSLYLE IRKMESQLQV LRFESDLDKC
ISLESSNDID DRPSSTSPST LKNPSINSIN RQTHDVEKES SDRDVPHLLD PDNNFNLKGN
PENPSSTFFT PEILSPKVYS DNVKDEPVED IFGFEDTSES SPGKPSQLRL QIEAFDDELA
DTASLGSVTT CLDQWQTFSD DTDSGFALNL YSSEDFRTDP YKEHDEFSMN SLSKWHSATS
DN
