ID   SEC8_NEUCR              Reviewed;        1111 AA.
AC   Q9HE88; Q7S7Q7;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Probable exocyst complex component sec8;
GN   Name=sec8; ORFNames=B13O20.150, NCU04190;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of sec3, sec5, sec6, sec8,
CC       sec10, sec15, exo70 and exo84. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL451015; CAC18205.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31914.3; -; Genomic_DNA.
DR   RefSeq; XP_961150.3; XM_956057.3.
DR   AlphaFoldDB; Q9HE88; -.
DR   SMR; Q9HE88; -.
DR   STRING; 5141.EFNCRP00000003757; -.
DR   EnsemblFungi; EAA31914; EAA31914; NCU04190.
DR   GeneID; 3877316; -.
DR   KEGG; ncr:NCU04190; -.
DR   VEuPathDB; FungiDB:NCU04190; -.
DR   HOGENOM; CLU_004025_0_0_1; -.
DR   InParanoid; Q9HE88; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
DR   GO; GO:0090522; P:vesicle tethering involved in exocytosis; IEA:InterPro.
DR   InterPro; IPR039682; Sec8/EXOC4.
DR   InterPro; IPR007191; Sec8_exocyst_N.
DR   PANTHER; PTHR14146; PTHR14146; 1.
DR   Pfam; PF04048; Sec8_exocyst; 1.
PE   3: Inferred from homology;
KW   Exocytosis; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1111
FT                   /note="Probable exocyst complex component sec8"
FT                   /id="PRO_0000118940"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1023..1057
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1033..1057
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1111 AA;  124417 MW;  6AC72D46750E7D0B CRC64;
     MADRYGQQPQ SYRGNSGFGN LGRRNDDYDP YGDGYPSDRY GTSTNPASRP STASRNAPPP
     RSAQRGRTGA GDMQIQSNAE RQIGNVLDLI KREWPAMVET DCIPVQLALQ LLDTSSVGRA
     HEYRNFQQTH QFLQESLKNI VHDHHQGFNS SIGTFHKIQG SIQSSQKKVR ALKESLAASK
     TALCTTNPEL KQLHATSRMY DGVLQTLNEL DDLRTVPDQL EARISEKRFL TAVEVLQNAL
     RKLRKPELDN IGALSDLRSY LANQETALMD ILVEELHEHL YLKSPYCQER WQNLAKVQGI
     SHETYGDAPG VAPFHGILDT IDWEKSVAED PQKNPEADTF YYVTLLVEAL NRLGRLETAV
     DMLKQRLPVE LFAVVNETIN DVDQKHPSSL RGGASGSHGL NIYGHRETRM RADVIHDLLS
     TLYGKFEAIA EGHRVLHEAI KALIRREGAG NNSVLLGGFK ELWNLYQNEI RALLHNYVTT
     DADVYQFSRT PRPGMGMNGR ADSARDNLFK FSEVDAKSAE MASEYEALDS IIRAAVPGLT
     DSTRRDNKKG SLIIPRSEPI TSRKSAGYGS GSSQQNSGTY KSLVEPSVFN MSLLLPPTLI
     FLQRLKSIVP PGSDLATSTL TSFLDNFLVN VFQPQLDETL GKLSDTVFGE ADAFQQDSDW
     AQVAKRPVYK GTTAFFTVIT AFCRMLGTIP HDQALSTLII TQMVRYYDRC FSWYKALVTK
     TQEGGDKQIR EKEKLRASAI LATEPSEVRE TIQRLWKSEN LNDLELLYRE VNQLIAWANG
     RDLDASDIIQ DRDMIQSMCL LYTSMKWLSV KIHGLRHITR NETDSSKSSF PTKAEKKRWT
     LLNDPSKATG GEAPVYLPMT EETVENFDSI LVSYDELAST ALLTLHLEIR TRILHSLQTA
     LSPLTTAPYL LDQEVNEPDP EILSLNSEMV AYDEILVRCL RLREVQFVRN GLGKLINGFL
     IKNAPMTAPM NAKGCGRMQL NILVLQQNLK NIEEGVDLVR ASNYFEMFER GVDAILEKAR
     EGVASSGSQE TGDAGRKSED AGEEGAETPN SRKSAEIFGD DKDRFSYDEL KALVELCYSE
     QLADPERGVA AAAKRQMADK LLNLSEYMWQ S