ID   SECBL_MYCS2             Reviewed;         146 AA.
AC   A0QUB2;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=SecB-like chaperone SmegB {ECO:0000303|PubMed:23264229};
GN   Name=secBL {ECO:0000303|PubMed:23264229};
GN   OrderedLocusNames=MSMEG_2143, MSMEI_2092; ORFNames=LJ00_10675;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=25657281; DOI=10.1128/genomea.01520-14;
RA   Mohan A., Padiadpu J., Baloni P., Chandra N.;
RT   "Complete genome sequences of a Mycobacterium smegmatis laboratory strain
RT   (MC2 155) and isoniazid-resistant (4XR1/R2) mutant strains.";
RL   Genome Announc. 3:E01520-E01520(2015).
RN   [5]
RP   FUNCTION, AND EXPRESSION IN E.COLI AND M.TUBERCULOSIS.
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=23264229; DOI=10.1007/s12192-012-0396-5;
RA   Sala A., Calderon V., Bordes P., Genevaux P.;
RT   "TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive
RT   toxin-antitoxin systems controlled by SecB-like chaperones.";
RL   Cell Stress Chaperones 18:129-135(2013).
CC   -!- FUNCTION: Chaperone component of an orphan antitoxin chaperone (AC)
CC       system; there is no toxin gene in close genomic proximity. When
CC       expressed in E.coli complements the cold-sensitive phenotype of a secB
CC       deletion, suggesting it may have a generic chaperone function. Does not
CC       however complement the toxin-neutralizing effect of its M.tuberculosis
CC       paralog Rv1957 (AC P95257) in E.coli, probably because the antitoxin
CC       genes are not from the same family. {ECO:0000269|PubMed:23264229}.
CC   -!- SIMILARITY: Belongs to the SecB-like family. {ECO:0000305}.
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DR   EMBL; CP000480; ABK76162.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP38562.1; -; Genomic_DNA.
DR   EMBL; CP009494; AIU07346.1; -; Genomic_DNA.
DR   RefSeq; WP_011728187.1; NZ_SIJM01000021.1.
DR   RefSeq; YP_886500.1; NC_008596.1.
DR   AlphaFoldDB; A0QUB2; -.
DR   SMR; A0QUB2; -.
DR   PRIDE; A0QUB2; -.
DR   EnsemblBacteria; ABK76162; ABK76162; MSMEG_2143.
DR   EnsemblBacteria; AFP38562; AFP38562; MSMEI_2092.
DR   GeneID; 66733567; -.
DR   KEGG; msb:LJ00_10675; -.
DR   KEGG; msg:MSMEI_2092; -.
DR   KEGG; msm:MSMEG_2143; -.
DR   PATRIC; fig|246196.56.peg.2145; -.
DR   eggNOG; ENOG5033GFD; Bacteria.
DR   HOGENOM; CLU_1739116_0_0_11; -.
DR   OMA; RPGDIHI; -.
DR   OrthoDB; 2083535at2; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   InterPro; IPR035958; SecB-like_sf.
DR   SUPFAM; SSF54611; SSF54611; 1.
PE   3: Inferred from homology;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..146
FT                   /note="SecB-like chaperone SmegB"
FT                   /id="PRO_0000432916"
SQ   SEQUENCE   146 AA;  15706 MW;  C481172E660BF6EA CRC64;
     MIERDGAPTF EDVQELLNRS ELTDVALYEH AGRRVDDAVD DEFSLQVLTR VGDTEFEIRC
     KVTAAGHGGQ YLADAGAVFT LQSAAKIEEG TAREFAEKVG VMAVYPYLRA AVSQSAASLG
     LDRPILPLLR AGGVKLTESM DSAEDA