SECB_HAEIN
ID SECB_HAEIN Reviewed; 169 AA.
AC P44853;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein-export protein SecB;
GN Name=secB; OrderedLocusNames=HI_0743;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX PubMed=11101901; DOI=10.1038/82040;
RA Xu Z., Knafels J.D., Yoshino K.;
RT "Crystal structure of the bacterial protein export chaperone secB.";
RL Nat. Struct. Biol. 7:1172-1177(2000).
CC -!- FUNCTION: One of the proteins required for the normal export of
CC preproteins out of the cell cytoplasm. It is a molecular chaperone that
CC binds to a subset of precursor proteins, maintaining them in a
CC translocation-competent state. It also specifically binds to its
CC receptor SecA.
CC -!- SUBUNIT: Homotetramer, a dimer of dimers. One homotetramer interacts
CC with 1 SecA dimer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the SecB family. {ECO:0000305}.
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DR EMBL; L42023; AAC22401.1; -; Genomic_DNA.
DR PIR; I64089; I64089.
DR RefSeq; NP_438902.1; NC_000907.1.
DR RefSeq; WP_005630575.1; NC_000907.1.
DR PDB; 1FX3; X-ray; 2.50 A; A/B/C/D=1-169.
DR PDB; 1OZB; X-ray; 2.80 A; A/B/C/D/E/F/G/H=1-169.
DR PDBsum; 1FX3; -.
DR PDBsum; 1OZB; -.
DR AlphaFoldDB; P44853; -.
DR SMR; P44853; -.
DR IntAct; P44853; 1.
DR STRING; 71421.HI_0743; -.
DR EnsemblBacteria; AAC22401; AAC22401; HI_0743.
DR KEGG; hin:HI_0743; -.
DR PATRIC; fig|71421.8.peg.779; -.
DR eggNOG; COG1952; Bacteria.
DR HOGENOM; CLU_111574_1_0_6; -.
DR OMA; CPNVLFP; -.
DR PhylomeDB; P44853; -.
DR BioCyc; HINF71421:G1GJ1-781-MON; -.
DR EvolutionaryTrace; P44853; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.420.10; -; 1.
DR HAMAP; MF_00821; SecB; 1.
DR InterPro; IPR003708; SecB.
DR InterPro; IPR035958; SecB-like_sf.
DR PANTHER; PTHR36918; PTHR36918; 1.
DR Pfam; PF02556; SecB; 1.
DR PRINTS; PR01594; SECBCHAPRONE.
DR SUPFAM; SSF54611; SSF54611; 1.
DR TIGRFAMs; TIGR00809; secB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chaperone; Cytoplasm; Protein transport; Reference proteome;
KW Translocation; Transport.
FT CHAIN 1..169
FT /note="Protein-export protein SecB"
FT /id="PRO_0000055378"
FT STRAND 17..31
FT /evidence="ECO:0007829|PDB:1FX3"
FT HELIX 35..38
FT /evidence="ECO:0007829|PDB:1FX3"
FT STRAND 51..59
FT /evidence="ECO:0007829|PDB:1FX3"
FT STRAND 62..71
FT /evidence="ECO:0007829|PDB:1FX3"
FT TURN 76..78
FT /evidence="ECO:0007829|PDB:1FX3"
FT STRAND 84..97
FT /evidence="ECO:0007829|PDB:1FX3"
FT HELIX 100..108
FT /evidence="ECO:0007829|PDB:1FX3"
FT HELIX 110..129
FT /evidence="ECO:0007829|PDB:1FX3"
FT HELIX 142..156
FT /evidence="ECO:0007829|PDB:1FX3"
FT HELIX 158..161
FT /evidence="ECO:0007829|PDB:1FX3"
SQ SEQUENCE 169 AA; 19132 MW; 047DCC722965EC7B CRC64;
MSEQKQDVAA TEEQQPVLQI QRIYVKDVSF EAPNLPHIFQ QEWKPKLGFD LSTETTQVGD
DLYEVVLNIS VETTLEDSGD VAFICEVKQA GVFTISGLED VQMAHCLTSQ CPNMLFPYAR
ELVSNLVNRG TFPALNLSPV NFDALFVEYM NRQQAENAEE KSEEEQTKH
