SECDF_BRUA2
ID SECDF_BRUA2 Reviewed; 758 AA.
AC Q2YNM0; Q57DL6; Q9ZG86;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Protein translocase subunit SecDF;
GN Name=secDF; OrderedLocusNames=BAB1_0910;
OS Brucella abortus (strain 2308).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=359391;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2308;
RX PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL Infect. Immun. 73:8353-8361(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-518.
RC STRAIN=2308;
RX PubMed=9826342; DOI=10.1128/iai.66.12.5684-5691.1998;
RA Vemulapalli R., Duncan A.J., Boyle S.M., Sriranganathan N., Toth T.E.,
RA Schurig G.G.;
RT "Cloning and sequencing of yajC and secD homologs of Brucella abortus and
RT demonstration of immune responses to YajC in mice vaccinated with B.
RT abortus RB51.";
RL Infect. Immun. 66:5684-5691(1998).
CC -!- FUNCTION: Part of the Sec protein translocase complex. Interacts with
CC the SecYEG preprotein conducting channel. SecDF uses the proton motive
CC force (PMF) to complete protein translocation after the ATP-dependent
CC function of SecA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the essential Sec protein translocation apparatus
CC which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and
CC YidC. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the SecD/SecF family.
CC SecD subfamily. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the SecD/SecF family.
CC SecF subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAJ10866.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AM040264; CAJ10866.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF085217; AAC83691.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2YNM0; -.
DR SMR; Q2YNM0; -.
DR STRING; 359391.BAB1_0910; -.
DR EnsemblBacteria; CAJ10866; CAJ10866; BAB1_0910.
DR KEGG; bmf:BAB1_0910; -.
DR PATRIC; fig|359391.11.peg.3221; -.
DR HOGENOM; CLU_007894_2_1_5; -.
DR PhylomeDB; Q2YNM0; -.
DR Proteomes; UP000002719; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR GO; GO:0043952; P:protein transport by the Sec complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01463_B; SecD_B; 1.
DR HAMAP; MF_01464_B; SecF_B; 1.
DR InterPro; IPR005791; SecD.
DR InterPro; IPR022813; SecD/SecF_arch_bac.
DR InterPro; IPR022645; SecD/SecF_bac.
DR InterPro; IPR022646; SecD/SecF_CS.
DR InterPro; IPR005665; SecF_bac.
DR PANTHER; PTHR30081; PTHR30081; 2.
DR Pfam; PF07549; Sec_GG; 2.
DR Pfam; PF02355; SecD_SecF; 2.
DR PRINTS; PR01755; SECFTRNLCASE.
DR TIGRFAMs; TIGR00916; 2A0604s01; 2.
DR TIGRFAMs; TIGR00966; 3a0501s07; 1.
DR TIGRFAMs; TIGR01129; secD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..758
FT /note="Protein translocase subunit SecDF"
FT /id="PRO_0000095959"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 579..599
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 682..702
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 706..726
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 758 AA; 81982 MW; 297DF4D28259901F CRC64;
MLYFSRWKSA LIWLAVLVSL IIASPNFFSR ETLENLPDFL PKKQVSLGLD LSGGSRLILQ
VQNAGKTDLE TTANIMRQRL EELGYGNPVV EGEGRNQIRV EVPGLYDAQL LKDILTIRGN
LSFRAMDDTM SPDDAIRGTP PADSEIVYSF DDPPVGYLLK KTPILTGHDI TDAKASISAD
DGQPVITLTL DDNGRRRLAD LTAQGNENSF AIVVDNQVVS APTVSGPLDT SELQIEGAFD
LQAANNMAVV LRSGALPQAV TVLEERTIAS ALGEDYASAA VLAALLAALV VGLFMVLSYG
ILGVIALVAL VVNIVILTAV LSLIGASISL ASIAGLVLTI GLAVDAHILI YERVREDRRK
GYSVVQAMES GFYRALSTIV DANLTTLIAA LVLFLLGSGT VHGFALTVAI GIGTTLFTTL
TFTRLLIAQW VRTAKPKEVP KRRLKLVPTV THIPFMRLQF VTLGISVLAC AIVVALFVNI
GFNYGIDFRG GSMVELQARN GDANLEDINE RLAELNIDSA RVLPAKSPRS ALVIIGSQEV
GDDAEQTVAV KLRGEFEQDY SFQRVDVVGP TVSEQLSRAG VLAVILSLIG IFIYVWFRFR
WQLALGAVLS TLHDVVILSG MFIVFRMEFN LWSVAAILTI IGYSLNDTVV IYDRVRENLR
RYKSAPLPAI IDASINQTLS RTLLTSFVTF LAHVPLYAFG GSEIRMFALA LSVGIIVASY
SSIFIAAPLL VQFGLKPRET DAGDAVDAEL AQSLNLES
