ID   SECD_HALVD              Reviewed;         524 AA.
AC   D4GTK5; Q8U4T9;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Protein-export membrane protein SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN   Name=secD {ECO:0000255|HAMAP-Rule:MF_01463}; OrderedLocusNames=HVO_1976;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN PROTEIN EXPORT, SUBUNIT,
RP   SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND PROBABLE OPERON STRUCTURE.
RC   STRAIN=DS2 / DS70, and DS2 / DSM 5716 / WFD11;
RX   PubMed=16452406; DOI=10.1128/jb.188.4.1251-1259.2006;
RA   Hand N.J., Klein R., Laskewitz A., Pohlschroder M.;
RT   "Archaeal and bacterial SecD and SecF homologs exhibit striking structural
RT   and functional conservation.";
RL   J. Bacteriol. 188:1251-1259(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
CC   -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-Rule:MF_01463,
CC       ECO:0000269|PubMed:16452406}.
CC   -!- SUBUNIT: Part of the protein translocation apparatus. Forms a homodimer
CC       and complexes with SecF. {ECO:0000269|PubMed:16452406}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01463,
CC       ECO:0000269|PubMed:16452406}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01463, ECO:0000269|PubMed:16452406}.
CC   -!- DISRUPTION PHENOTYPE: A double secD and secF deletion grows very poorly
CC       on solid medium at 45 degrees Celsius, confers a severe cold-sensitive
CC       growth phenotype (30 degrees Celsius), as well as having defects in
CC       Sec-dependent protein translocation. Has no effects on Sec-independent
CC       Tat substrate protein export. {ECO:0000269|PubMed:16452406}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01463}.
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DR   EMBL; AF395892; AAL74409.1; -; Genomic_DNA.
DR   EMBL; CP001956; ADE03176.1; -; Genomic_DNA.
DR   RefSeq; WP_004041855.1; NC_013967.1.
DR   AlphaFoldDB; D4GTK5; -.
DR   STRING; 309800.C498_05151; -.
DR   EnsemblBacteria; ADE03176; ADE03176; HVO_1976.
DR   GeneID; 8926304; -.
DR   KEGG; hvo:HVO_1976; -.
DR   eggNOG; arCOG03055; Archaea.
DR   HOGENOM; CLU_007894_5_0_2; -.
DR   OMA; RPAYGDI; -.
DR   OrthoDB; 14000at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01463_A; SecD_A; 1.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR024912; SecD_arc.
DR   PANTHER; PTHR30081; PTHR30081; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..524
FT                   /note="Protein-export membrane protein SecD"
FT                   /id="PRO_0000412202"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
SQ   SEQUENCE   524 AA;  55006 MW;  2EE8F5294F4CEBC0 CRC64;
     MSTLRDNWRV IFLVAAILLS TFALFSPTMG NQSPIGEDDS ATNLQFGLQL DGGTRIRAPL
     VGVTAEDVEF EGDSERVVER QVAAQIAGAD AADIIVRTGA ESSTVEATIE NVTADDLSAA
     LDAAGYAHGE VRDGVTGTTR AETVRVLQSK INEAGLSGGT VQQVTTATGE HFILVEVPNR
     DQSDVVDLVG ERGTVQIDIY YPTGTDNGSR TYETREAVLT QADFTSIGTA QESQTGSGAF
     VPVSVRDDPA AEFQTAIQDT GLAQPGGTRC TYMEDGGRNT TEGCLLLVVN GEVVNAFGMS
     GGLADTMRAG EWAGAPSFQL QTRNTSEAQE IAINLRAGAL PARLDLSGED SGTSSYISPS
     QGESFKFDSL ITGIVAVLAV AGVVFIRYGK PQVALPMIVT GLSEVYILLG FAAAIGYPLD
     LSVIAGFIAV IGTGVDDLII IADEVMGEGS VKSRKVFQSR FRRAFWVIGA AAATTIIAMS
     PLAVLSLGDL QGFAIFTILG VIVGVLVTRP AYGDILRLLL TEDR