ID   SECD_METKA              Reviewed;         403 AA.
AC   Q8TWM4;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein-export membrane protein SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN   Name=secD {ECO:0000255|HAMAP-Rule:MF_01463}; OrderedLocusNames=MK1009;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-
CC       Rule:MF_01463}.
CC   -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC       with SecF. {ECO:0000255|HAMAP-Rule:MF_01463}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01463};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01463}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01463}.
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DR   EMBL; AE009439; AAM02222.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TWM4; -.
DR   SMR; Q8TWM4; -.
DR   STRING; 190192.MK1009; -.
DR   EnsemblBacteria; AAM02222; AAM02222; MK1009.
DR   KEGG; mka:MK1009; -.
DR   HOGENOM; CLU_007894_5_1_2; -.
DR   OMA; SAHLQMM; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01463_A; SecD_A; 1.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR022646; SecD/SecF_CS.
DR   InterPro; IPR024912; SecD_arc.
DR   PANTHER; PTHR30081; PTHR30081; 1.
DR   Pfam; PF07549; Sec_GG; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..403
FT                   /note="Protein-export membrane protein SecD"
FT                   /id="PRO_0000412687"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
SQ   SEQUENCE   403 AA;  43385 MW;  44534461B3FDFC46 CRC64;
     MSGLGWMKEN WRLLVITAVW IVAATSLAVK GVNLGLELKG GTMVIAKTDH PVSKKEMDQT
     VTVLESRLST FGFKGIKIQP VGRDHIIVML PGTPPKEAVE LITKPGRFEA KYKGKTVITG
     QDIESVESPR IERVEGGYQW SVPFRLTAEG ARKFAEVAKN APGQPIDMYL DNKKVSSPRI
     SEDLAMAAAS GHMEREIEIV GGAKTKEQAE REAKEIMAVL RSGQLPAKLV PEGVYSVSAT
     LGQNFLKMAM IAGAIAFAAV SVIIALRYRD IRISGPILFT GSSEVVFLIG LASLTGFTID
     LPALAGIILS IGSGVDDLIV ITDEIVRGER RKEEVTLRQR IKRAFSVVLA SFATLAAAMA
     VLFVAGMGLL KGFAIMTIAG AFYGVVITRP VYADLLKKIL GTE