SECD_PSEAE
ID SECD_PSEAE Reviewed; 620 AA.
AC Q9HXI1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein translocase subunit SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN Name=secD {ECO:0000255|HAMAP-Rule:MF_01463}; OrderedLocusNames=PA3821;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Part of the Sec protein translocase complex. Interacts with
CC the SecYEG preprotein conducting channel. SecDF uses the proton motive
CC force (PMF) to complete protein translocation after the ATP-dependent
CC function of SecA. {ECO:0000255|HAMAP-Rule:MF_01463}.
CC -!- SUBUNIT: Forms a complex with SecF. Part of the essential Sec protein
CC translocation apparatus which comprises SecA, SecYEG and auxiliary
CC proteins SecDF-YajC and YidC. {ECO:0000255|HAMAP-Rule:MF_01463}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01463}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01463}.
CC -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01463}.
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DR EMBL; AE004091; AAG07208.1; -; Genomic_DNA.
DR PIR; F83169; F83169.
DR RefSeq; NP_252510.1; NC_002516.2.
DR RefSeq; WP_003100609.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; Q9HXI1; -.
DR SMR; Q9HXI1; -.
DR STRING; 287.DR97_4048; -.
DR PaxDb; Q9HXI1; -.
DR PRIDE; Q9HXI1; -.
DR EnsemblBacteria; AAG07208; AAG07208; PA3821.
DR GeneID; 878279; -.
DR KEGG; pae:PA3821; -.
DR PATRIC; fig|208964.12.peg.4000; -.
DR PseudoCAP; PA3821; -.
DR HOGENOM; CLU_007894_4_3_6; -.
DR InParanoid; Q9HXI1; -.
DR OMA; MVVYYRL; -.
DR PhylomeDB; Q9HXI1; -.
DR BioCyc; PAER208964:G1FZ6-3892-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0043952; P:protein transport by the Sec complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01463_B; SecD_B; 1.
DR InterPro; IPR005791; SecD.
DR InterPro; IPR027398; SecD-TM.
DR InterPro; IPR022813; SecD/SecF_arch_bac.
DR InterPro; IPR022645; SecD/SecF_bac.
DR InterPro; IPR022646; SecD/SecF_CS.
DR PANTHER; PTHR30081; PTHR30081; 1.
DR Pfam; PF07549; Sec_GG; 1.
DR Pfam; PF13721; SecD-TM1; 1.
DR Pfam; PF02355; SecD_SecF; 1.
DR TIGRFAMs; TIGR00916; 2A0604s01; 1.
DR TIGRFAMs; TIGR01129; secD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..620
FT /note="Protein translocase subunit SecD"
FT /id="PRO_0000287813"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 488..507
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 511..533
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
SQ SEQUENCE 620 AA; 67675 MW; BA8740DB46A099FD CRC64;
MLNKYPLWKY LLILAVLAVG FIYSAPNLYP DDPAVQISGA STALQVTQAD VDRAAKALTD
AGIAVKADSL SKKGGLIRLV KQDDQLPAKE VVRRTLGDDY VVALNLAQTT PEWLRKLGGS
PMKLGLDLSG GVHFLLEVDM DKAVDARLKV YESEVKSLLR KERVRYRSLP IQDRAIQLGF
TDSESLDKAR SLIAKDFRDF EVVPEERNGL QVLRVALTQA KLAEIREYSI KQNLTTVRNR
VNELGVSEPL VQRQGANRIV VELPGVQDTA EAKRILGKTA NLEFRLAAEP DALKSATETF
EFREPRRPPV PLERGVIITG DQVTDASASF DENGRPQVNI RLDGHGGELM NRATRNNVGR
SMAVVFIEQK PVTRYTKQMV DGVEKEVAVP AFKEEKQIIS LATIQSPLGN QFRITGLDGP
GESSELALLL RAGGLAAPMY FAEERTIGPS LGADNIAKGI DASLWGMLFV SLFIIVIYRF
FGVIATVALA FNMVMLVALM SILGATLTLP GIAGIVLTMG MAVDANVLIF SRIREELANG
MSVQRAIHEG FNRAFTAILD ANLTSLLVGG ILYAMGTGPV KGFAVTMSLG IITSMFTAIM
VTRAMVNLIF GGRDFKKLWI
