ID   SECD_PYRFU              Reviewed;         505 AA.
AC   Q8U4B4;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein-export membrane protein SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN   Name=secD {ECO:0000255|HAMAP-Rule:MF_01463}; OrderedLocusNames=PF0174;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-
CC       Rule:MF_01463}.
CC   -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC       with SecF. {ECO:0000255|HAMAP-Rule:MF_01463}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01463};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01463}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01463}.
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DR   EMBL; AE009950; AAL80298.1; -; Genomic_DNA.
DR   RefSeq; WP_011011287.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U4B4; -.
DR   SMR; Q8U4B4; -.
DR   STRING; 186497.PF0174; -.
DR   TCDB; 3.A.5.7.2; the general secretory pathway (sec) family.
DR   PRIDE; Q8U4B4; -.
DR   EnsemblBacteria; AAL80298; AAL80298; PF0174.
DR   GeneID; 41711965; -.
DR   KEGG; pfu:PF0174; -.
DR   PATRIC; fig|186497.12.peg.181; -.
DR   eggNOG; arCOG03055; Archaea.
DR   HOGENOM; CLU_007894_5_1_2; -.
DR   OMA; SAHLQMM; -.
DR   OrthoDB; 14000at2157; -.
DR   PhylomeDB; Q8U4B4; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01463_A; SecD_A; 1.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR022646; SecD/SecF_CS.
DR   InterPro; IPR024912; SecD_arc.
DR   PANTHER; PTHR30081; PTHR30081; 1.
DR   Pfam; PF07549; Sec_GG; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..505
FT                   /note="Protein-export membrane protein SecD"
FT                   /id="PRO_0000412688"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
SQ   SEQUENCE   505 AA;  55814 MW;  A06E2ED0B4A6B86F CRC64;
     MKWRRILLNF RVIVLIFFLL ISITALATRG LTFGLDISGG ISITVKLEKP VDSQTMEQVK
     IALEQRLNTL GVKNIVVEPW GDQFVIVKVA NVTEEEADQL IKTIERQGVF YAEFQGIIFA
     TGKDILNVGS VSYDPQHSAW VVPFRLSKEA AEKFAQLALG KAGYPVDMFL DPPVNSTLVV
     SNRVYEAMLS KTFMLEGDMT LVERIEKAFG IKVVPYANVT PEEIAEIAKG SERIILLDVD
     GNLSKALKEM GFEVETRSMR SDEDVYDFIK RSLGLYGPYR VSEGLATGNP STEVMISITA
     PKTDIQARQD AQVVSVVLRS GSLPVKLSIE RIDYISPKLG ENFKRQVLVA GIAALLVVGL
     IVFLHYRKIK IAIPVMFTSF SEVLIILGIA ALIRWNLDLP SIAGIIAAIG TGVDQQIVIT
     DELLGEEESR RRVKRSGVLR RMGRAFFIIL ASATTTIVAM SFLFKFFVGG LRGFAFTTIL
     GVLVGIFITR PAYGEIAKVL IGERR