SECD_THEGJ
ID SECD_THEGJ Reviewed; 525 AA.
AC C5A3H4;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Protein-export membrane protein SecD {ECO:0000255|HAMAP-Rule:MF_01463};
GN Name=secD {ECO:0000255|HAMAP-Rule:MF_01463}; OrderedLocusNames=TGAM_0284;
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3;
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-
CC Rule:MF_01463}.
CC -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC with SecF. {ECO:0000255|HAMAP-Rule:MF_01463}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01463};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01463}.
CC -!- SIMILARITY: Belongs to the SecD/SecF family. SecD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01463}.
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DR EMBL; CP001398; ACS32786.1; -; Genomic_DNA.
DR RefSeq; WP_015857905.1; NC_012804.1.
DR AlphaFoldDB; C5A3H4; -.
DR STRING; 593117.TGAM_0284; -.
DR PaxDb; C5A3H4; -.
DR EnsemblBacteria; ACS32786; ACS32786; TGAM_0284.
DR GeneID; 7988940; -.
DR KEGG; tga:TGAM_0284; -.
DR PATRIC; fig|593117.10.peg.287; -.
DR eggNOG; arCOG03055; Archaea.
DR HOGENOM; CLU_007894_5_1_2; -.
DR OMA; MARAFFI; -.
DR OrthoDB; 14000at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01463_A; SecD_A; 1.
DR InterPro; IPR022813; SecD/SecF_arch_bac.
DR InterPro; IPR024912; SecD_arc.
DR PANTHER; PTHR30081; PTHR30081; 1.
DR Pfam; PF02355; SecD_SecF; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Protein transport; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..525
FT /note="Protein-export membrane protein SecD"
FT /id="PRO_0000412689"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01463"
SQ SEQUENCE 525 AA; 57348 MW; 66FF6EF17C5225C4 CRC64;
MARKKGVKAL LLNWRVLLLI LFLIGSVVSM SIKGLTYGID IGGGVALIAE PEKPVSKDTL
NGIITSLQNR LNTFGVKDIT IEAQHDPETG QSLIVVKIAN VTLDEANQIK DLIESQGVLY
MEFNGVIFAT GTDVTVHSSD YGLDLQECPT CWYVGFELSG KAQNKFKKIA AGKLGWPIDI
YLDPPVNSLL VVSPRVYQEM NSGDFMGAPS EGTPKPLVER LKEAFNITVV EYSNQTAEDI
VENATALGKD KIILADVPEE LYNDVRELVL SKDLKLRVSH YTPQQGEDLK DFVKRILNLY
GPYVLKFDPA KGETTRLKLS GSAPTKEEAL QEARKIYSVL RSGSLAVKLH VVSEEYISPT
LGASFKKQAI IAGIGALIAV LLIVYFHYRR WRIAIPVAST SLFEVIIILG IAALIRWNLD
LPSIAGIIAA IGTGVDQQIV ITDELLGGTA GRVTRRMSAL RRMARAFFII FASAATTIVA
MSFLLVYFVG TLKGFAVTTI LGVLIGVLVT RPAYAEIAKY LLSLE
