SECE_PYRFU
ID SECE_PYRFU Reviewed; 61 AA.
AC Q8TZK2;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Protein translocase subunit SecE {ECO:0000255|HAMAP-Rule:MF_00422};
DE AltName: Full=Protein transport protein Sec61 gamma subunit homolog {ECO:0000255|HAMAP-Rule:MF_00422};
GN Name=secE {ECO:0000255|HAMAP-Rule:MF_00422}; OrderedLocusNames=PF1989;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE SECYE COMPLEX WITH AN OPEN
RP LATERAL GATE, SUBUNIT, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=20855604; DOI=10.1073/pnas.1012556107;
RA Egea P.F., Stroud R.M.;
RT "Lateral opening of a translocon upon entry of protein suggests the
RT mechanism of insertion into membranes.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:17182-17187(2010).
CC -!- FUNCTION: Essential subunit of the protein translocation channel
CC SecYEG. Clamps together the 2 halves of SecY. May contact the channel
CC plug during translocation.
CC -!- SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer
CC consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The
CC heterotrimers can form oligomers, although 1 heterotrimer is thought to
CC be able to translocate proteins. Interacts with the ribosome. May
CC interact with SecDF, and other proteins may be involved.
CC {ECO:0000269|PubMed:20855604}.
CC -!- INTERACTION:
CC Q8TZK2; Q8U019: secY; NbExp=5; IntAct=EBI-9025109, EBI-9025098;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00422,
CC ECO:0000269|PubMed:20855604}; Single-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_00422, ECO:0000269|PubMed:20855604}.
CC -!- SIMILARITY: Belongs to the SecE/SEC61-gamma family. {ECO:0000255|HAMAP-
CC Rule:MF_00422}.
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DR EMBL; AE009950; AAL82113.1; -; Genomic_DNA.
DR RefSeq; WP_011013133.1; NC_003413.1.
DR PDB; 3MP7; X-ray; 2.90 A; B=1-61.
DR PDBsum; 3MP7; -.
DR AlphaFoldDB; Q8TZK2; -.
DR SMR; Q8TZK2; -.
DR DIP; DIP-59388N; -.
DR IntAct; Q8TZK2; 2.
DR STRING; 186497.PF1989; -.
DR TCDB; 3.A.5.7.2; the general secretory pathway (sec) family.
DR EnsemblBacteria; AAL82113; AAL82113; PF1989.
DR GeneID; 1469873; -.
DR KEGG; pfu:PF1989; -.
DR PATRIC; fig|186497.12.peg.2065; -.
DR eggNOG; arCOG02204; Archaea.
DR HOGENOM; CLU_191921_0_1_2; -.
DR OMA; DFLHQCR; -.
DR OrthoDB; 131429at2157; -.
DR EvolutionaryTrace; Q8TZK2; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0009306; P:protein secretion; IEA:UniProtKB-UniRule.
DR GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.820; -; 1.
DR HAMAP; MF_00422; SecE; 1.
DR InterPro; IPR023391; Prot_translocase_SecE_dom_sf.
DR InterPro; IPR008158; Translocase_Sec61-g.
DR InterPro; IPR001901; Translocase_SecE/Sec61-g.
DR SUPFAM; SSF103456; SSF103456; 1.
DR TIGRFAMs; TIGR00327; secE_euk_arch; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..61
FT /note="Protein translocase subunit SecE"
FT /id="PRO_0000104225"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT TRANSMEM 35..55
FT /note="Helical"
FT TOPO_DOM 56..61
FT /note="Extracellular"
FT HELIX 11..15
FT /evidence="ECO:0007829|PDB:3MP7"
FT HELIX 17..21
FT /evidence="ECO:0007829|PDB:3MP7"
FT HELIX 29..58
FT /evidence="ECO:0007829|PDB:3MP7"
SQ SEQUENCE 61 AA; 6932 MW; 77791007C8F416B6 CRC64;
MAELQERIRH FWKESRRAFL VTKKPNWATY KRAAKITGLG IILIGLIGML IRIVGILILG
G
