ID   SECE_THEMA              Reviewed;          65 AA.
AC   P35874;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 140.
DE   RecName: Full=Protein translocase subunit SecE {ECO:0000255|HAMAP-Rule:MF_00422};
GN   Name=secE {ECO:0000255|HAMAP-Rule:MF_00422}; OrderedLocusNames=TM_0452;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=1429627; DOI=10.1016/s0021-9258(18)50016-8;
RA   Liao D., Dennis P.P.;
RT   "The organization and expression of essential transcription translation
RT   component genes in the extremely thermophilic eubacterium Thermotoga
RT   maritima.";
RL   J. Biol. Chem. 267:22787-22797(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (4.50 ANGSTROMS) OF SECYEG IN COMPLEX WITH SECA.
RX   PubMed=18923516; DOI=10.1038/nature07335;
RA   Zimmer J., Nam Y., Rapoport T.A.;
RT   "Structure of a complex of the ATPase SecA and the protein-translocation
RT   channel.";
RL   Nature 455:936-943(2008).
CC   -!- FUNCTION: Essential subunit of the protein translocation channel
CC       SecYEG. Clamps together the 2 halves of SecY. May contact the channel
CC       plug during translocation.
CC   -!- SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer
CC       consisting of SecY, SecE and SecG subunits. The heterotrimers can form
CC       oligomers, although 1 heterotrimer is thought to be able to translocate
CC       proteins. Interacts with SecDF, and other proteins may be involved. The
CC       channel interacts with SecA via subunit SecY.
CC       {ECO:0000269|PubMed:18923516}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the SecE/SEC61-gamma family. {ECO:0000255|HAMAP-
CC       Rule:MF_00422}.
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DR   EMBL; Z11839; CAA77865.1; -; Genomic_DNA.
DR   EMBL; AE000512; AAD35535.1; -; Genomic_DNA.
DR   PIR; E72375; E72375.
DR   RefSeq; NP_228262.1; NC_000853.1.
DR   RefSeq; WP_004081514.1; NZ_CP011107.1.
DR   PDB; 3DIN; X-ray; 4.50 A; D/G=1-65.
DR   PDBsum; 3DIN; -.
DR   AlphaFoldDB; P35874; -.
DR   SMR; P35874; -.
DR   DIP; DIP-59808N; -.
DR   IntAct; P35874; 3.
DR   STRING; 243274.THEMA_02430; -.
DR   TCDB; 3.A.5.1.4; the general secretory pathway (sec) family.
DR   EnsemblBacteria; AAD35535; AAD35535; TM_0452.
DR   KEGG; tma:TM0452; -.
DR   eggNOG; COG0690; Bacteria.
DR   InParanoid; P35874; -.
DR   OMA; SKFWIFL; -.
DR   OrthoDB; 1974284at2; -.
DR   EvolutionaryTrace; P35874; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0009306; P:protein secretion; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   GO; GO:0043952; P:protein transport by the Sec complex; IBA:GO_Central.
DR   Gene3D; 1.20.5.1030; -; 1.
DR   HAMAP; MF_00422; SecE; 1.
DR   InterPro; IPR005807; SecE_bac.
DR   InterPro; IPR038379; SecE_sf.
DR   InterPro; IPR001901; Translocase_SecE/Sec61-g.
DR   PANTHER; PTHR33910; PTHR33910; 1.
DR   Pfam; PF00584; SecE; 1.
DR   TIGRFAMs; TIGR00964; secE_bact; 1.
DR   PROSITE; PS01067; SECE_SEC61G; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..65
FT                   /note="Protein translocase subunit SecE"
FT                   /id="PRO_0000104190"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT   TRANSMEM        35..51
FT                   /note="Helical"
FT   TOPO_DOM        52..65
FT                   /note="Extracellular"
SQ   SEQUENCE   65 AA;  7314 MW;  A9EAC82A8E92947A CRC64;
     MEKLRKFFRE VIAEAKKISW PSRKELLTSF GVVLVILAVT SVYFFVLDFI FSGVVSAIFK
     ALGIG