ID   SECF_METTH              Reviewed;         287 AA.
AC   O26936;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Protein-export membrane protein SecF {ECO:0000255|HAMAP-Rule:MF_01464};
GN   Name=secF {ECO:0000255|HAMAP-Rule:MF_01464}; OrderedLocusNames=MTH_848;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-
CC       Rule:MF_01464}.
CC   -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC       with SecD. {ECO:0000255|HAMAP-Rule:MF_01464}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01464};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01464}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecF subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01464}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB85346.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB85346.1; ALT_FRAME; Genomic_DNA.
DR   PIR; B69213; B69213.
DR   AlphaFoldDB; O26936; -.
DR   SMR; O26936; -.
DR   STRING; 187420.MTH_848; -.
DR   EnsemblBacteria; AAB85346; AAB85346; MTH_848.
DR   KEGG; mth:MTH_848; -.
DR   PATRIC; fig|187420.15.peg.832; -.
DR   HOGENOM; CLU_060478_0_0_2; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01464_A; SecF_A; 1.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR024921; SecF_arc.
DR   PANTHER; PTHR30081; PTHR30081; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Protein-export membrane protein SecF"
FT                   /id="PRO_0000412204"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
SQ   SEQUENCE   287 AA;  30839 MW;  3C5C8896117BF1A2 CRC64;
     MGETLKVIVL IDRILKSYRP LIAIPAAITV IALLLVVFNG LNESVDLKGG ALAELTLEKS
     VTQAELESLL REKLGTGDIK VLSIRGERVT VQFGTDMDVV KVSEALRGTA TINSYKAVGP
     VLSKQAMNQI YWAIGFAFLF MSVTVFIIFR DPVPSLAVIL AAASDIIIAV GGMSLFGIPL
     SLASVGAILM LIGYSVDTDI LLTTRVLKRR KGTINERALG AMKTGVTMSI AAIASMAALY
     LVTVFVMPEA RVLSDIAAVL IIGLLADILT TWLMNLGILR WYLEVRS