ID   SECF_PYRFU              Reviewed;         296 AA.
AC   Q8U4B5;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Protein-export membrane protein SecF {ECO:0000255|HAMAP-Rule:MF_01464};
GN   Name=secF {ECO:0000255|HAMAP-Rule:MF_01464}; OrderedLocusNames=PF0173;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
CC   -!- FUNCTION: Involved in protein export. {ECO:0000255|HAMAP-
CC       Rule:MF_01464}.
CC   -!- SUBUNIT: Part of the protein translocation apparatus. Forms a complex
CC       with SecD. {ECO:0000255|HAMAP-Rule:MF_01464}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01464};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01464}.
CC   -!- SIMILARITY: Belongs to the SecD/SecF family. SecF subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01464}.
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DR   EMBL; AE009950; AAL80297.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8U4B5; -.
DR   STRING; 186497.PF0173; -.
DR   TCDB; 3.A.5.7.2; the general secretory pathway (sec) family.
DR   EnsemblBacteria; AAL80297; AAL80297; PF0173.
DR   KEGG; pfu:PF0173; -.
DR   PATRIC; fig|186497.12.peg.180; -.
DR   eggNOG; arCOG03054; Archaea.
DR   HOGENOM; CLU_060478_0_0_2; -.
DR   OMA; DLMNTYL; -.
DR   PhylomeDB; Q8U4B5; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006605; P:protein targeting; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01464_A; SecF_A; 1.
DR   InterPro; IPR022813; SecD/SecF_arch_bac.
DR   InterPro; IPR024921; SecF_arc.
DR   PANTHER; PTHR30081; PTHR30081; 1.
DR   Pfam; PF02355; SecD_SecF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..296
FT                   /note="Protein-export membrane protein SecF"
FT                   /id="PRO_0000412711"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01464"
SQ   SEQUENCE   296 AA;  32397 MW;  E085185740790F68 CRC64;
     MPEVDNVIKE KLKLLVEMDP KKMIIYPLIV FGIAIIIIIA NYVMTGSFVK EGIELRGGSV
     ITLQGVNVSP DEIAKSIKEK TGIDVTVEKF SGVGGSGVRV YVSAGDDVNL VREALKEMFP
     DVEPQTVVIG PTFGEIVREQ GIKAIVYAFI GMAIVVFLFF RVPVPSMTVV FSAFSDMIIA
     IALMNIFGIE LSQATIAALL MLIGYSVDSN ILLTTRLLRR KEFTVEEAYY SSLKTGFTMS
     TTTLGALASL WIFSTAQVID DIASVLIFGL LADFMNTWIL NAGVLRLYIA KREGKE