ID   SECG_DICDI              Reviewed;         986 AA.
AC   Q54KA7; P90525;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Ankyrin repeat, PH and SEC7 domain containing protein secG;
GN   Name=secG; ORFNames=DDB_G0287459;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 756-980.
RC   STRAIN=AX4;
RA   Loomis W.F., Iranfar N.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB36958.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000101; EAL63695.1; -; Genomic_DNA.
DR   EMBL; U78755; AAB36958.1; ALT_FRAME; mRNA.
DR   RefSeq; XP_637214.1; XM_632122.1.
DR   AlphaFoldDB; Q54KA7; -.
DR   SMR; Q54KA7; -.
DR   STRING; 44689.DDB0191439; -.
DR   PaxDb; Q54KA7; -.
DR   EnsemblProtists; EAL63695; EAL63695; DDB_G0287459.
DR   GeneID; 8626150; -.
DR   KEGG; ddi:DDB_G0287459; -.
DR   dictyBase; DDB_G0287459; secG.
DR   eggNOG; KOG0930; Eukaryota.
DR   eggNOG; KOG4177; Eukaryota.
DR   HOGENOM; CLU_302561_0_0_1; -.
DR   InParanoid; Q54KA7; -.
DR   OMA; DHEPCGI; -.
DR   PhylomeDB; Q54KA7; -.
DR   PRO; PR:Q54KA7; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0005764; C:lysosome; IDA:dictyBase.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR   GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR   GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR   GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR   GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   Gene3D; 1.25.40.20; -; 4.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 5.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 15.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 13.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..986
FT                   /note="Ankyrin repeat, PH and SEC7 domain containing
FT                   protein secG"
FT                   /id="PRO_0000334489"
FT   REPEAT          34..63
FT                   /note="ANK 1"
FT   REPEAT          68..97
FT                   /note="ANK 2"
FT   REPEAT          101..131
FT                   /note="ANK 3"
FT   REPEAT          135..164
FT                   /note="ANK 4"
FT   REPEAT          168..197
FT                   /note="ANK 5"
FT   REPEAT          201..230
FT                   /note="ANK 6"
FT   REPEAT          234..263
FT                   /note="ANK 7"
FT   REPEAT          267..296
FT                   /note="ANK 8"
FT   REPEAT          300..329
FT                   /note="ANK 9"
FT   REPEAT          334..363
FT                   /note="ANK 10"
FT   REPEAT          367..396
FT                   /note="ANK 11"
FT   REPEAT          400..429
FT                   /note="ANK 12"
FT   REPEAT          433..462
FT                   /note="ANK 13"
FT   REPEAT          466..495
FT                   /note="ANK 14"
FT   REPEAT          499..528
FT                   /note="ANK 15"
FT   DOMAIN          580..770
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   DOMAIN          784..895
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          911..986
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        920..986
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  107523 MW;  3AB5789F4A39788D CRC64;
     MGSTSNSTKN TGSTTTTTTT AAPATTAKHS NSAPTRPSVH YYSSTGDIEK LSNLLNNSAT
     SPDTPDSEKR TPLHHAAFCG SAACVNFLLD KKANANIKDS AGNTPLQWAS SRGHLECIKL
     LVEKGGVDVN TKDDKNGTPL HKASLFASAE CVLYLLNGKA DPRAVTTNGE TPLHHASAGG
     NPQCVELLIK ADSKVNAVDN DCITPLHQAS FSGHSSCVSL LLKKGAKVDP RDIHGISPLH
     NAASAGYVDC VEQLVRNGEN INCVDIEGVT PLHHTCFNGN LQLTKRLIEL GAKINMVDEM
     GETPLHKAAF NGHKEVCEYL LYLDPTMIDC RDSRQSTSLH LAAFNGLLDM VDLLIRYKAQ
     INIKDEEGAT PLHKASFNGH SSCAKLLVDK GAPICIVDSQ GATPLHKAAF NGRSKCLATL
     IRSGAELEVK DSQGGTPLHN AAYNGHSDCC RILLKKGANV NAVDTHSSTP LHLASAAGAR
     DTVDVLIQFK ARIDAKNFAG KTPLVYAIKK NHSDVARVLI RAGADLDQVS LRSSVDFTKT
     FGTENHDEIY QIVNKRESSN HEVDELQLAL EQQAKEDMEQ LAAEKQKLLL IKAAIAQFNS
     HPKKGIEFIV ANGVISEKNP KEVAHFLLTH SELSKQSIGE YIGEGDDFNL QVLHAFVDEL
     NFFGLDFDVA LRKYLLTFRL PGEAQKIDRM MEKFASQFYQ HNPENKVFVN QDAVYVLAFS
     VIMLNTDAHN PNIKKKMTKA EFLRNNSGIN SGDDLPPDFM ENLYDKIVTN EIKMERDGNQ
     ANQHVEKKGW LTKQGGRIKT WKKRWFILTA NCLLYYKTPQ DHEPCGIIPL ENVVVTIDPQ
     KKFCFMLHSS QEQMKACKLN SDGTLVQANH AAYFIAAANM AEMDSWVQSI KSNIHSNPNF
     EQLLKRKAET IRGRGKVSTK PIQNRKQTIS GPPPSTTTTT TSTASNNVTS VGSPPNSGSV
     LNSSGSKPVT FSSTSSPVQQ QTSALS