ID   SECG_STAA8              Reviewed;          91 AA.
AC   Q2G026;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Protein translocase subunit SecG;
GN   OrderedLocusNames=SAOUHSC_00801;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   ROLE IN EXPORT, AND DISRUPTION PHENOTYPE.
RC   STRAIN=RN4220, and SH1000;
RX   PubMed=20472795; DOI=10.1128/jb.01452-09;
RA   Sibbald M.J., Winter T., van der Kooi-Pol M.M., Buist G., Tsompanidou E.,
RA   Bosma T., Schafer T., Ohlsen K., Hecker M., Antelmann H., Engelmann S.,
RA   van Dijl J.M.;
RT   "Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 192:3788-3800(2010).
CC   -!- FUNCTION: Subunit of the protein translocation channel SecYEG (By
CC       similarity). While not essential, it considerably increases the export
CC       efficiency of extracellular proteins. {ECO:0000250,
CC       ECO:0000269|PubMed:20472795}.
CC   -!- SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer
CC       consisting of SecY, SecE and SecG subunits. The heterotrimers can form
CC       oligomers, although 1 heterotrimer is thought to be able to translocate
CC       proteins. Interacts with SecDF, and other proteins may be involved. The
CC       channel interacts with SecA via subunit SecY (By similarity). Also part
CC       of the accessory SecA2/SecY2 protein translocation apparatus required
CC       to export cell wall protein GspB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Grows normally, a double secG/secY2 mutant enters
CC       stationary phase earlier. Significant differences in the export pattern
CC       of a number of extracellular proteins are seen in a secG deletion; the
CC       double secG/secY2 mutant exacerbates this effect (shown in RN4220).
CC       Single or double deletions are as virulent as wild-type (shown in
CC       RN4220 and SH1000). {ECO:0000269|PubMed:20472795}.
CC   -!- SIMILARITY: Belongs to the SecG family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29929.1; -; Genomic_DNA.
DR   RefSeq; YP_499357.2; NC_007795.1.
DR   AlphaFoldDB; Q2G026; -.
DR   SMR; Q2G026; -.
DR   STRING; 1280.SAXN108_0846; -.
DR   EnsemblBacteria; ABD29929; ABD29929; SAOUHSC_00801.
DR   GeneID; 3919364; -.
DR   KEGG; sao:SAOUHSC_00801; -.
DR   PATRIC; fig|93061.5.peg.725; -.
DR   eggNOG; COG1314; Bacteria.
DR   HOGENOM; CLU_094156_6_1_9; -.
DR   OMA; VTVMMQP; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR   GO; GO:0065002; P:intracellular protein transmembrane transport; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   GO; GO:0043952; P:protein transport by the Sec complex; IBA:GO_Central.
DR   InterPro; IPR004692; SecG.
DR   PANTHER; PTHR34182; PTHR34182; 1.
DR   Pfam; PF03840; SecG; 1.
DR   PRINTS; PR01651; SECGEXPORT.
DR   TIGRFAMs; TIGR00810; secG; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..91
FT                   /note="Protein translocase subunit SecG"
FT                   /id="PRO_0000414189"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10106 MW;  D3021EAF4FB45EAB CRC64;
     MIYYLSYIRN GGQFMHTFLI VLLIIDCIAL ITVVLLQEGK SSGLSGAISG GAEQLFGKQK
     QRGVDLFLNR LTIILSILFF VLMICISYLG M