ID   SECM_CROS8              Reviewed;         167 AA.
AC   A7MQ64;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332}; OrderedLocusNames=ESA_03241;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of the
CC       secM secA operon. Translational pausing at a specific Pro residue 5
CC       residues before the end of the protein may allow disruption of a mRNA
CC       repressor helix that normally suppresses secA translation initiation.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC       active form is cytosolic, while the periplasmic form is rapidly
CC       degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABU78463.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000783; ABU78463.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A7MQ64; -.
DR   EnsemblBacteria; ABU78463; ABU78463; ESA_03241.
DR   KEGG; esa:ESA_03241; -.
DR   HOGENOM; CLU_108853_0_0_6; -.
DR   OrthoDB; 1814644at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Periplasm; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT   CHAIN           39..167
FT                   /note="Secretion monitor"
FT                   /id="PRO_0000314443"
SQ   SEQUENCE   167 AA;  18306 MW;  33D09A0F768F419E CRC64;
     MPGIFTRWRQ FGRRYFWPHL LLGMVAASLG LPALNNNAEP AAPAEASTSH TGTLRSFDSL
     ALISETSRRS ASFGVDYWQQ HAIRTVIRHL SFAMAPQALP MAMEESLPLN AQHLALLDTL
     SAMLTQDLQP AAAQVQPAPR LLPPLSFTVS AWIRQVQGIR AGPRLLA