SECM_ECO57
ID SECM_ECO57 Reviewed; 170 AA.
AC P62397; P58327;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE Flags: Precursor;
GN Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN OrderedLocusNames=Z0107, ECs0101;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Regulates secA expression by translational coupling of the
CC secM secA operon. Translational pausing at a specific Pro residue 5
CC residues before the end of the protein may allow disruption of a mRNA
CC repressor helix that normally suppresses secA translation initiation.
CC {ECO:0000255|HAMAP-Rule:MF_01332}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC active form is cytosolic, while the periplasmic form is rapidly
CC degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG54401.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB33524.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG54401.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB33524.1; ALT_INIT; Genomic_DNA.
DR PIR; E85492; E85492.
DR PIR; E90641; E90641.
DR RefSeq; NP_308128.2; NC_002695.1.
DR RefSeq; WP_000014320.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P62397; -.
DR STRING; 155864.EDL933_0100; -.
DR EnsemblBacteria; AAG54401; AAG54401; Z0107.
DR EnsemblBacteria; BAB33524; BAB33524; ECs_0101.
DR GeneID; 58460763; -.
DR GeneID; 913588; -.
DR KEGG; ece:Z0107; -.
DR KEGG; ecs:ECs_0101; -.
DR PATRIC; fig|386585.9.peg.201; -.
DR eggNOG; ENOG5031JGK; Bacteria.
DR HOGENOM; CLU_108853_0_0_6; -.
DR OMA; NYWQQHA; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR HAMAP; MF_01332; SecM; 1.
DR InterPro; IPR009502; SecM.
DR Pfam; PF06558; SecM; 1.
DR PIRSF; PIRSF004572; SecM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT CHAIN 38..170
FT /note="Secretion monitor"
FT /id="PRO_0000031989"
SQ SEQUENCE 170 AA; 18866 MW; 5B4B3001056CAD22 CRC64;
MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLS