SECM_ECO7I
ID SECM_ECO7I Reviewed; 170 AA.
AC B7NHK3;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE Flags: Precursor;
GN Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN OrderedLocusNames=ECIAI39_0100;
OS Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI39 / ExPEC;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Regulates secA expression by translational coupling of the
CC secM secA operon. Translational pausing at a specific Pro residue 5
CC residues before the end of the protein may allow disruption of a mRNA
CC repressor helix that normally suppresses secA translation initiation.
CC {ECO:0000255|HAMAP-Rule:MF_01332}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The
CC active form is cytosolic, while the periplasmic form is rapidly
CC degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
CC -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC Rule:MF_01332}.
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DR EMBL; CU928164; CAR16241.1; -; Genomic_DNA.
DR RefSeq; WP_000014316.1; NC_011750.1.
DR RefSeq; YP_002406149.1; NC_011750.1.
DR AlphaFoldDB; B7NHK3; -.
DR STRING; 585057.ECIAI39_0100; -.
DR EnsemblBacteria; CAR16241; CAR16241; ECIAI39_0100.
DR KEGG; ect:ECIAI39_0100; -.
DR PATRIC; fig|585057.6.peg.109; -.
DR HOGENOM; CLU_108853_0_0_6; -.
DR OMA; NYWQQHA; -.
DR Proteomes; UP000000749; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR HAMAP; MF_01332; SecM; 1.
DR InterPro; IPR009502; SecM.
DR Pfam; PF06558; SecM; 1.
DR PIRSF; PIRSF004572; SecM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Periplasm; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01332"
FT CHAIN 38..170
FT /note="Secretion monitor"
FT /id="PRO_1000142335"
SQ SEQUENCE 170 AA; 18846 MW; 4FF47BE1056CAD22 CRC64;
MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
TLSALLTQEG TPSEKGYHID YAHFTPQAKF STPVWISQAQ GIRAGPQRLS